多囊卵巢综合征病人妊娠并发症的临床观察

THE CLINICAL OBSERVATION OF PREGNANCY COMPLICATIONS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME

目的:回顾性分析多囊卵巢综合征(PCOS)病人的妊娠结局以及对妊娠的影响,并探求有预测价值的影响因素,从而使妊娠结局以及新生儿的出生质量得到改善。方法:选取2015-01~2017-12期间本院165例单胎妊娠的PCOS病人作为研究组,同期就诊的160例健康单胎妊娠孕妇作为对照组。比较两组的一般资料、激素水平、妊娠并发症以及新生儿状况等。结果:(1)PCOS组较对照组病人孕前体质指数(BMI)高(P<0.05)。PCOS组较对照组早产率及剖宫产率升高、流产率增加(比较差异均有统计学意义,P<0.05)。死胎比较无统计学意义,每组各有死胎1例;(2)PCOS组与对照组比较,妊娠期高血压、妊娠期糖尿病发生率显著增高(P<0.05),羊水过多、羊水过少、产后出血、胎膜早破等发生率无统计学意义(P>0.05);(3)两组发生低体重儿、巨大儿、胎儿窒息相比较无差异(P>0.05);(4)PCOS组较对照组LH/FSH、LH、T、INS水平高,差异有统计学意义(P<0.05)。结论:PCOS病人妊娠期流产、早产、剖宫产以及合并妊娠期高血压、妊娠期糖尿病的发生率增加,新生儿不良结局也增加。PCOS病人孕前BMI、LH、LH/FSH、T、INS水平升高,可能是PCOS不良妊娠结局的重要因素。

Objective:To review analysis the pregnancy outcomes of patients with polycycstic ovary syndrome(PCOS),and explore the influence factors of predictive value,to improve the pregnancy outcome and quality of newborn babies.Methods:165 single pregnant women with PCOS in our hospital form January 2015 to December 2017 were selected as the study groups(PCOS Group).160 single pregnant women without PCOS were selected as the control group.The general indexs,hormone level,pregnant complication and newborn situation so on of wowen in PCOS Group were compared with that of Control Group.Results:Compared with Control Group,patients with PCOS have a significantly higher BMI( P < 0.05 ).the preterm birth rate,cesarean section rate and abortion rate increased in the PCOS Group(The differences were statistically significant,P < 0.05 ).There was no statistically significant difference in stillbirth between the two groups,with 1 stillbirth in each group.The incidence of gestational hypertension disease and gestational diabetes increased significantly in PCOS Group than that in Control Group( P < 0.05 ).There was no statistically significant difference about the incidence of polyhydramnios,Oligohydramnios,postpartum hemorrhage,premature rupture of membranes and so on between the two groups( P > 0.05 ).No significant difference could be discovered about low birth weight,fetal macrosomia,neonatal asphyxia between PCOS Group and Control Group( P > 0.05 ).luteinizing hormone/Serum follicle-stimulating hormone(LH/FSH),luteinizing hormone(LH),total testosterone(T),fasting insulin(INS)of PCOS Group were significantly difference from that of Control Group( P < 0.05 ).Conclusion:Patients with PCOS have more adverse the incidence during pregnancy,include mainly the preterm birth,cesarean section and abortion,gestational hypertension disease and gestational diabetes.in addition,They have more adverse outcomes for newborns too.PCOS Patients have more higher BMI、LH、LH/FSH、T、INS before pregnancy,that may be important factors of adverse pregnancy outcome of PCOS Patients.