VCAM1与NF-κB在妊娠期肝内胆汁淤积症患者胎盘中的表达及意义

Expressions of VCAM1 and NF-κB in placenta of patients with intrahepatic cholestasis during pregnancy and their significance

目的探讨血管内皮细胞黏附分子-1(VCAM-1)与核因子(NF-κB)在妊娠期肝内胆汁淤积症患者胎盘中的表达及意义.方法回顾性分析2017年5月至2018年9月本院收治的80例妊娠期肝内胆汁淤积症患者(观察组)及60例正常妊娠孕妇(对照组)的临床资料,测定两组受检者VCAM1及NF-κB水平,分析其在胎盘组织中的表达情况.结果观察组患者胎盘组织中NF-κB、VCAM-1阳性率分别为71.25%(57/80)、67.50%(54/80),均高于对照组25.00%(15/60)、21.67%(13/60),差异均有统计学意义(均P< 0.05);经Spearman等级相关分析发现,VCAM-1与NF-κB表达呈明显正相关(r=0.592,P=0.000).结论妊娠期肝内胆汁淤积症患者胎盘组织中VCAM-1与NF-κB均升高,且浓度呈正相关,推测NF-κB活化升高促进了VCAM-1的表达.

Objective To investigate the expressions vascular endothelial cell adhesion molecule-1 (VCAM-1) and nuclear factor (NF-κB) in placenta of patients with intrahepatic cholestasis during pregnancy and their significance.Methods The clinical data of 80 patients with intrahepatic cholestasis during pregnancy (an observation group) and 60 normal pregnant women (a control group) hospitalized into our hospital from May,2017 to September,2018 were retrospectively analyzed.The levels of VCAM 1 and NF-κB in the two groups were measured.Their expressions in placenta were analyzed.Results The positive rates of NF-κB and VCAM-1 were higher in the observation group than in the control group [71.25%(57/80) vs.25.00%(15/60) and 67.50%(54/80) vs.21.67%(13/60)],with statistical differences (both P < 0.05).Spearman grade correlation analysis showed that there was a positive correlation between VCAM-1 and NF-κB (r=0.592,P=-0.000).Conclusion VCAM-1 and NF-κB in the placenta of patients with intrahepatic cholestasis during pregnancy increase,and positively correlate with each other.It is speculated that the increase of NF-κd3 activation promotes the expression of VCAM-1.