呼吸机相关性肺炎患者呼出气冷凝液中pH及亚硝酸盐检测的临床意义

Clinical significance of pH and nitrite detection in exhaled breath condensate in patients with ventilatorassociated pneumonia

目的探究呼吸机相关性肺炎患者呼出气冷凝液中pH及亚硝酸盐检测的意义。方法在2012年6月至2017年12月之间展开本次研究,选择对应时间段内40例胃食管反流病合并呼吸机相关性肺炎患者作为观察组,另选择对应时间段内40例胃食管反流病未合并呼吸机相关性肺炎患者作为对照组;对两组患者均实施呼出气冷凝液中pH及亚硝酸盐检测,观察其检测结果.并实施组间对比分析。结果呼吸机相关性肺炎患者的呼出气冷凝液中NOJ会出现上升、pH值会出现下降,且与未出现呼吸机相关性肺炎患者对比差异均有统计学意义(P < 0.05 )。结论呼出气冷凝液中pH及亚硝酸盐检测,可从一定程度上反映患者的机体状态,将呼吸机相关性肺炎患者和无肺炎患者做出区分,为临床准确治疗提供指导。

Objective To explore the significance of pH and nitrite detection in exhaled breath condensate of patients with ventilator-associated pneumonia. Methods The study was conducted between June 2012 and December 2017. 40 patients with gastroesophageal reflux disease and ventilator-associated pneumonia were selected as the observation group, and 40 patients with gastroesophageal reflux disease without ventilatorassociated pneumonia were selected as the control group. The pH and nitrite detection of exhaled breath condensate were performed in both groups. The detection results were observed and compared between the two groups. Results In patients with ventilator-associated pneumonia, NO2 increased in exhaled breath condensate, pH decreased, with statistically significant differences compared with patients without ventilator-associated pneumonia (P<0.05). Conclusion The detection of pH and nitrite in exhaled breath condensate can reflect the patients' body state to some extent, and distinguish patients with ventilator-associated pneumonia from patients without pneumonia, providing guidance for clinically accurate treatment.