胺碘酮联合酒石酸美托洛尔治疗急性心肌梗死并发快速心律失常临床研究

Clinical study of amiodarone combined with metoprolol tartrate in the treatment of acute myocardial infarction complicated with rapid arrhythmia

目的探究胺碘酮联合酒石酸美托洛尔治疗急性心肌梗死并发快速心律失常的临床效果。方法选择2016年2月至2017年6月胶州市人民医院收治的104例急性心肌梗死并发快速心律失常患者,按随机数表法分为对照组(52例)和试验组(52例)。在常规治疗基础上,对照组接受胺碘酮治疗,试验组接受胺碘酮联合酒石酸美托洛尔治疗,均治疗1个月。对比两组治疗效果、不良反应发生情况及治疗前、治疗1个月后心功能[左心室射血分数(LVEF)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)]水平。结果试验组治疗1个月后总有效率90. 38%较对照组69. 23%高(P <0. 05)。两组治疗1个月后LVEF水平均较治疗前增高,且试验组较对照组高(P <0. 05)。两组治疗1个月后LVESD及LVEDD水平较治疗前降低,且试验组较对照组低(P <0. 05)。试验组不良反应发生率13. 46%与对照组9. 62%对比,差异无统计学意义(P> 0. 05)。结论对急性心肌梗死并发快速心律失常患者采取胺碘酮联合酒石酸美托洛尔治疗效果显著,可改善患者心功能,且安全性良好。

Objective To investigate the effect of amiodarone combined with metoprolol tartrate in the treatment of acute myocardial infarction complicated with rapid arrhythmia.MethodsA total of 104 patients with acute myocardial infarction complicated with rapid arrhythmia treated in Jiaozhou People's Hospital from May of 2016 to June of 2017 were selected and divided into control group and experimental group,52 cases in each group.On the basis of routine treatment,the control group was treated with amiodarone,and the experimental group was treated with amiodarone combined with metoprolol tartrate.Both groups were treated for one month.The therapeutic effect,adverse reactions and cardiac function,including left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)before and after treatment for 1 month were compared between the two groups.ResultsThe total effective rate of the experimental group was 90.38%,higher than that of the control group 69.23%(P<0.05).The level of LVEF after 1 month of treatment was higher than that before treatment,and that in experimental group was higher than control group(P<0.05).The level of LVESD and LVEDD after 1 month of treatment were lower than those before treatment,and those in experimental group were lower than control group(P<0.05).The incidence of adverse reactions was 13.46%in the experimental group and 9.62%in the control group,and there was no significant difference(P>0.05).ConclusionAmiodarone combined with metoprolol tartrate has a good effect in the treatment of acute myocardial infarction complicated with rapid arrhythmia,can improve cardiac function with good safety.