注射用丹参多酚酸盐联合替格瑞洛治疗不稳定型心绞痛的效果观察

Effect of salvianolic acid injection combined with ticagrelor on unstable angina pectoris

目的研究注射用丹参多酚酸盐联合替格瑞洛治疗不稳定型心绞痛的效果。方法选取82例不稳定型心绞痛患者作为研究对象,按照随机抽签法分组,各41例。两组均接受常规治疗,对照组在常规治疗基础上接受替格瑞洛治疗,观察组在对照组基础上接受注射用丹参多酚酸盐治疗。治疗2周后,比较两组治疗效果、心绞痛改善情况、治疗前及治疗2周后血液流变学(红细胞聚集指数、血浆黏度)及血小板聚集率。结果观察组总有效率92. 68%较对照组73. 17%高(P <0. 05);观察组治疗2周后心绞痛发作频率较对照组低,发作持续时间较对照组短(P <0. 05);治疗2周后,观察组红细胞聚集指数、血浆黏度、血小板聚集率较对照组低(P <0. 05)。结论注射用丹参多酚酸盐联合替格瑞洛治疗不稳定型心绞痛效果显著,可明显减轻心绞痛症状,降低血小板聚集率,改善血液流变学。

Objective To investigate the effect of salvianolic acid injection combined with ticagrelor on unstable angina pectoris.MethodsEighty-two patients with unstable angina pectoris were selected as the research objects and randomly divided into two groups,41 cases in each group.Both two groups received routine treatment,and the control group received ticagrelor on the basis of routine treatment,while the observation group received salvianolic acid injection combined with ticagrelor on the basis of routine treatment.After 2 weeks of treatment,the effect of treatment,improvement of angina pectoris,hemorheology(erythrocyte aggregation index,plasma viscosity)and platelet aggregation rate before and after treatment were compared between the two groups.ResultsThe total effective rate of observation group was 92.68%,higher than control group with 73.17%(P<0.05).Compared with control group,the attack frequency in the observation group was lower and duration of angina pectoris was shorter after 2 weeks of treatment(P<0.05).After 2 weeks of treatment,the erythrocyte aggregation index,plasma viscosity and platelet aggregation rate in the observation group were lower than those in the control group(P<0.05).ConclusionSalvianolic acid injection combined with ticagrelor has a remarkable effect in the treatment of unstable angina pectoris.It can obviously relieve the symptoms of angina pectoris,reduce the platelet aggregation rate and improve hemorheology.