GBS培养联合阴道假丝酵母菌检测预测足月前胎膜早破的价值研究

Study on the value of GBS culture combined with candida vaginalis detection for predicting preterm premature rupture of membranes

目的探讨B族链球菌(GBS)及外阴阴道假丝酵母菌病(VVC)联合检测用于预测未足月胎膜早破(PPROM的价值。方法选取2016年8月～2017年8月我院收住的符合入选标准的PPROM孕妇227例为观察组,入院后立即行GBS培养、阴道假丝酵母菌检测;随机选取同期足月正常分娩的孕妇743例为对照组,于妊娠35～37周进行GBS培养、阴道假丝酵母菌检测;并记录两组孕妇年龄、孕周、体重指数、孕次、产次等一般资料。观察两组孕妇GBS及VVC的阳性率及两者之间的关系。结果两组孕妇的基本资料比较,差异无统计学意义(P>0.05);227例PPROM孕妇中,GBS阳性率为9.69%,明显高于对照组的5.11%,且差异有统计学意义(P<0.05);观察组VVC阳性率为25.11%,明显高于对照组的18.71%,且差异有统计学意义(P<0.05);VVC阳性组孕妇GBS阳性率9.69%高于VVC阴性组5.30%,且差异有统计学意义(P<0.05)。结论 GBS或VVC阳性均可增加PPROM发生的风险,有必要在妊娠35周前常规行GBS筛查及VVC检测来预测PPROM发生的风险,并对阳性者进行治疗。

Objective To investigate the value of combined detection of group B streptococcus(GBS)and vulvovaginal candidiasis(VVC)for predicting preterm premature rupture of membranes(PPROM).Methods A total of 227 pregnant women with PPROM who were hospitalized from August 2016 to August 2017 were selected as observation group.Immediately after admission,patients were given GBS culture and detection of Candida vaginalis.743 cases of pregnant women with term delivery in the same period were randomly selected as the control group,and were given GBS culture and detection of Candida vaginalis at 35-37th week of pregnancy.General data such as age,gestational weeks,body mass index,pregnancy time,and parity of the two groups were recorded.The positive rates of GBS and VVC and the relationship between them were observed.Results There was no significant difference in the basic data between the two groups(P>0.05).Among the 227 pregnant women with PPROM,the positive rate of GBS was 9.69%,which was significantly higher than that of the control group(5.11%),and the difference was statistically significant(P<0.05).The positive rate of VVC in the observation group was 25.11%,which was significantly higher than that in the control group(18.71%),and the difference was statistically significant(P<0.05).The positive rate of GBS in pregnant women with positive VVC was 9.69%,higher than that in those with negative VVC,and the difference was statistically significant(P<0.05).Conclusion Positive GBS or VVC can increase the risk of PPROM.It is necessary to routinely perform GBS screening and VVC testing before 35 weeks of gestation to predict the risk of PPROM and treat the patients with positive results.