可控性微结构多孔β-TCP生物陶瓷在颌骨骨缺损修复中的临床应用

Clinical application of controllable microstructured porous β-TCP bioceramics in the repair of jawbone defects

目的探讨可控性微结构多孔β-TCP生物陶瓷在颌骨骨缺损修复中的临床应用。方法选择2016年1月～2017年1月我科收治的颌骨骨缺损病例60例,随机分为实验组和对照组各30例。实验组在术中应用可控性微结构多孔β-TCP生物陶瓷修复颌骨缺损骨腔;对照组未植入任何骨替代材料。研究两组术后骨愈合情况,骨腔感染率及可控性微结构多孔β-TCP生物陶瓷在机体的排斥反应。结果实验组术后创口均Ⅰ期愈合,无排斥不良反应发生,术后3月复查CT提示骨愈合良好。对照组术后创口感染6例,病理性骨折1例,分别经抗感染和保守治疗后治愈,术后3月复查CT,缺损骨腔未见明显改变。结论可控性微结构多孔β-TCP生物陶瓷作为新型的骨替代材料能有效修复颌骨骨缺损,消除骨缺损死腔,有效降低缺损骨腔引起的感染、病理性骨折等问题,具有较好的应用前景。

Objective To investigate the clinical application of controllable microstructured porousβ-TCP bioceramics in the repair of jawbone defects.Methods From January 2016 to January 2017,60 cases of jawbone defects who were admitted to our department were randomly assigned to the experimental group and the control group,with 30 cases in each group.In the experimental group,the controllable microstructured porousβ-TCP bioceramic was used to repair the bone cavity of the jawbone defect.The control group was not implanted with any bone replacement material.The postoperative bone healing,bone cavity infection rate,and the rejection of the controllable microstructured porousβ-TCP bioceramics in the body were studied in both groups.Results In the experimental group,the wounds were healed at stage I after surgery,and no rejection and adverse reactions occurred.A review of CT at 3 months after surgery indicated that the bone was healed well.In the control group,there were 6 cases of postoperative wound infection and 1 case of pathological fractures,who were cured after anti-infection and conservative treatment.CT was reexamined 3 months after surgery,and no obvious changes were found in the defected bone cavity.Conclusion Controllable microstructured porousβ-TCP bioceramics can effectively repair jawbone defects as a new bone replacement material,eliminate the dead cavity of bone defect,effectively reduce the infection and pathological fractures caused by the defected bone cavity,and has a good application prospect.