子宫和卵巢腺瘤样瘤的临床病理分析

Clinicopathological analysis of uterus and ovarian adenomatoid tumors

目的探讨子宫和卵巢腺瘤样瘤的临床病理特点、免疫组化表达及鉴别诊断。方法回顾性分析2016年1月～2017年12月期间在我院进行子宫及卵巢切除术的315例患者标本,其中发现有20例子宫和卵巢腺瘤样瘤标本,对其临床病理特点及免疫组化表达进行分析,并复习相关文献。结果 20例腺瘤样瘤为手术标本的6.34%,其中子宫腺瘤样瘤18例、卵巢腺瘤样瘤2例。肿瘤平均直径为(2.52±0.17)cm,分别位于肌壁间、浆膜下或子宫近浆膜下;免疫组化染色结果显示CK(AE1/AE3)、MC、calretinin阳性,CD34,ER,PR,Desmin阴性;术后随访无恶性病变和复发情况出现。结论子宫和卵巢腺瘤样瘤相对较罕见,临床特征无特异性,易误诊和漏诊,正确运用免疫组化可提高子宫和卵巢腺瘤样瘤的检出率。

Objective To investigate the clinicopathological features,immunohistochemical expression and differential diagnosis of uterine and ovarian adenomatoid tumors.Methods 315 specimens of patients who underwent uterus and oophorectomy in our hospital from January 2016 to December 2017 were retrospectively analyzed,including 20 specimens of uterus and ovarian adenomatoid tumors.Their clinicopathological features and immunohistochemical expression were analyzed and related literature was reviewed.Results 20 cases of adenomatoid tumors were 6.34%of surgical specimens,including 18 cases of uterine adenomatoid tumors and 2 cases of ovarian adenomatoid tumors.The average diameter of the tumor was(2.52±0.17)cm,and the tumor was located between the muscle wall,subserosal or uterine subserosal.Immunohistochemical staining showed CK(AE1/AE3),MC and calretinin were positive,CD34,ER,PR and Desmin were negative.No malignant lesions and recurrence occurred during follow-up after surgery.Conclusion Uterine and ovarian adenomatoid tumors are relatively rare,without specific clinical features,which is easy to be misdiagnosed and missed diagnosis.Correct use of immunohistochemistry can improve the detection rate of uterine and ovarian adenomatoid tumors.