支链氨基酸转移酶1与恶性肿瘤

Branched chain amino acid transferase 1 and malignant tumors

支链氨基酸转移酶1(BCAT1)作为催化支链氨基酸代谢的关键酶,参与多种生物合成的通路。研究发现BCAT1在白血病、胶质瘤、鼻咽癌、胃癌、乳腺癌等恶性肿瘤中高表达,与肿瘤细胞的增殖、侵袭及转移密切相关,在肿瘤的发生发展中扮演重要角色,可作为恶性肿瘤新的治疗靶点。

As a key enzyme that catalyzes the metabolism of branched chain amino acids,branched chain amino acid transferase 1(BCAT1)is often involved in a variety of biosynthetic pathways.Reaserches show that BCAT1 is highly expressed in many kinds of malignant tumors such as leukemia,glioma,nasopharyngeal carcinoma,gastric cancer and breast cancer,et al,suggesting a close relationship with the proliferation,invasion and metastasis of tumor cells.Thus,BCAT1 plays an important role in the genesis and progression of tumor,and may have the potential to be a new therapeutic target.