低频重复经颅磁刺激联合利培酮治疗老年精神分裂症的疗效和安全性评价

Efficacy and Safety of Low Frequency Repetitive Transcranial Magnetic Stimulation Combined with Risperidone in the Treatment of Senile Schizophrenia

目的研究低频重复经颅磁刺激联合利培酮治疗老年精神分裂症的疗效和安全性。方法研究对象为方便选取老年精神分裂症患者,例数100例,采用抽签分组方式对研究对象100例进行分组,患者收取时间在2017年12月—2018年8月,分为观察组、对照组,分别实施低频重复经颅磁刺激联合利培酮治疗和单一治疗,对比各项指标。结果治疗后,观察组老年精神分裂症患者术后1周PANSS评分(80.64±1.56)分、术后2周(69.82±1.34)分、术后4周(47.64±1.32)分均低于对照组,差异有统计学意义(P<0.05);观察组第2周(24.64±1.67)分、第4周(25.86±1.97)分、第6周的MMSE评分(25.64±1.87)分与对照组相比较,差异有统计学意义(t=3.050 5、4.908 5、2.171 4,P<0.05);观察组老年精神分裂症患者不良反应发生率4.00%低于对照组,差异有统计学意义(χ2=7.161 8,P<0.05)。结论低频重复经颅磁刺激联合利培酮治疗老年精神分裂症的疗效十分显著。

Objective To study the efficacy and safety of low frequency repetitive transcranial magnetic stimulation com-bined with risperidone in the treatment of senile schizophrenia. Methods The study subjects were elderly patients with schizophrenia. The number of patients was 100. The subjects were grouped by lottery. The patients were collected from De-cember 2017 to August 2018, and were divided into observation group and the control group, low-frequency repetitive transcranial magnetic stimulation combined with risperidone treatment and single treatment were performed, and the indica-tors were compared. Results After treatment, the PANSS score (80.64±1.56)points, 2 weeks after surgery (69.82±1.34)points, and 4 weeks after surgery (47.64±1.32)points were lower in the observation group. The difference was statistically significant (P<0.05). The MMSE score (25.64±1.87)points of the 2nd week (24.64±1.67)points, the 4th week (25.86±1.97)points, and the 6th week of the observation group were compared with the control group. There were significant differences (t=3.050 5, 4.908 5, 2.171 4,P<0.05). The incidence of adverse reactions in the elderly patients with schizophrenia in the observation group was 4.00% lower than that in the control group, and the difference was statistically significant (X^2=7.161 8,P<0.05). Conclusion Low-frequency repetitive transcranial magnetic stimulation combined with risperidone is effective in the treat-ment of senile schizophrenia.