氧氟沙星与替硝唑腹腔灌注治疗输卵管阻塞所致女性不孕的临床观察

Clinical Observation of Intraperitoneal Infusion of Ofloxacin and Tinidazole in the Treatment of Female Infertility Caused by Tubal Obstruction

目的探讨氧氟沙星与替硝唑腹腔灌注治疗输卵管阻塞所致女性不孕的临床效果。方法随机选取2015年5月—2017年5月该院收治的输卵管阻塞所致女性不孕患者80例,依据治疗方法将这些患者分为氧氟沙星与替硝唑腹腔灌注治疗组(腹腔灌注组,n=40)和氧氟沙星与替硝唑静脉滴注治疗组(静脉滴注组,n=40)两组,对两组患者的输卵管通畅情况、临床疗效进行统计分析。结果腹腔灌注组患者的输卵管双侧通畅率、一侧通畅率47.5%(19/40)、40.0%(16/40)均显著高于静脉滴注组25.0%(10/40)、32.5%(13/40)(P<0.05),双侧通而不畅率、双侧堵塞率10.0%(4/40)、2.5%(1/40)均显著低于静脉滴注组30.0%(12/40)、12.5%(5/40)(P<0.05)。腹腔灌注组患者中治愈19例,有效16例,治疗的总有效率为87.5%(35/40);静脉滴注组患者中治愈10例,有效13例,治疗的总有效率为57.5%(23/40)。腹腔灌注组患者治疗的总有效率显著高于静脉滴注组(P<0.05)。结论氧氟沙星与替硝唑腹腔灌注较静脉滴注治疗输卵管阻塞所致女性不孕的临床效果好。

Objective To explore the clinical effect of infusion of ofloxacin and tinidazole in the treatment of female infer-tility caused by tubal obstruction. Methods A total of 80 female infertility patients with fallopian tube obstruction admitted to our hospital from May 2015 to May 2017 were randomly selected. According to the treatment, these patients were divided into the treatment group of ofloxacin and tinidazole intraperitoneal perfusion (peritoneal perfusion, n=40) and ofloxacin and tinidazole intravenous infusion group (intravenous infusion group, n=40), the two groups of patients with tubal patency and clinical efficacy were statistically analyzed. Results In the peritoneal perfusion group, the bilateral patency rate of the fal-lopian tube and the patency rate of one side were 47.5%(19/40) and 40.0%(16/40), which were significantly higher than the 25.0%(10/40) and 32.5%(13/40)(P<0.05) of the intravenous infusion group, bilateral patency rate, bilateral occlusion rate 10.0%(4/40), 2.5%(1/40) were significantly lower than the intravenous infusion group 30.0%(12/40), 12.5%(5/40)(P< 0.05). In the peritoneal perfusion group, 19 patients were cured and 16 patients were effective. The total effective rate was 87.5%(35/40). In the intravenous drip group, 10 patients were cured and 13 patients were effective. The total effective rate was 57.5%(23/40). The total effective rate of treatment in the peritoneal perfusion group was significantly higher than that in the intravenous infusion group (P<0.05). Conclusion The clinical effect of intraperitoneal infusion of ofloxacin and tinida-zole is better than that of female infertility caused by tubal obstruction.