凝血酶原时间与血小板指标检测对肝硬化疾病患者诊断的效果分析

Analysis of the Effect of Prothrombin Time and Platelet Index Detection on the Diagnosis of Patients with Liver Cirrhosis

目的分析凝血酶原时间与血小板检验方式对肝硬化疾病患者诊断效果。方法研究阶段为2016年3月—2018年3月,共方便选取研究对象280例,其中138例肝硬化患者作为观察组,纳入同期健康体检者142名,均全部接受凝血酶原时间、血小板检验,比较两组指标变化情况以及是否有统计学差异。结果观察组患者的凝血酶原时间为(19.42±3.22)s明显高于对照组患者的凝血酶原时间为(12.56±0.89)s,差异有统计学意义(t=5.396,P<0.05)。两组平均血小板平均体积、血小板分布宽度差异无统计学意义(P>0.05);观察组血小板计数、血小板压积分别为(70.68±33.84)×109/L、(0.07±0.04)%,与对照组差异有统计学意义(t=9.022,7.946,P<0.05)。出血患者的凝血酶原时间(20.51±3.64)s高于未出血者(17.74±2.46)s(t=7.307,P<0.05);出血者PLT、PCT低于未出血者,对比组间差异有统计学意义(t=8.306,7.119,P<0.05)。结论对于肝硬化通过检测凝血酶原时间以及血小板各指标可作为其诊断依据以及反映严重程度的相关指标,通过进行相应临床检测可为预防肝硬化患者出血有积极意义,值得临床推广。

Objective To analyze the diagnostic effect of prothrombin time and platelet test on patients with liver cirrhosis. Methods The study period was from March 2016 to March 2018. A total of 280 subjects were convenient included in the study. Among them, 138 patients with cirrhosis were included in the observation group, and 142 healthy subjects were in-cluded in the same period as the control group. All of them received prothrombin time and platelet test, compared the changes in the two groups of indicators and whether there was a statistical difference. Results The prothrombin time of the observation group was (19.42±3.22) s, which was significantly higher than that of the control group (12.56±0.89) s. The dif-ference was statistically significant (t=5.396, P<0.05). There was no statistically significant difference in mean platelet mean volume and platelet distribution width between the two groups (P>0.05). The platelet count and platelet pressure in the ob-servation group were (70.68±33.84)×10^9/L,(0.07±0.04)%, respectively, which were different from the control group (t=9.022, 7.946, P<0.05). The prothrombin time of patients with bleeding (20.51±3.64)s was higher than that of those without bleeding (17.74±2.46) s (t=7.307, P<0.05). The difference of PLT and PCT was lower than that of non-bleeding. The results were sta-tistically significant (t=8.306, 7.119, P<0.05). Conclusion The detection of prothrombin time and platelet markers for liver cirrhosis can be used as the basis for diagnosis and related indicators to reflect the severity. It is worthy of clinical promo-tion to prevent bleeding in patients with cirrhosis by conducting corresponding clinical tests.