维生素D的多重神经活性及其潜在的抗抑郁机制研究进展

Advances in research on multiple neuroactivities of vitamin D and treatment of depression

抑郁症在世界范围内普遍存在,并导致死亡率的增加以及生活质量的下降。越来越多的证据表明抑郁症可能与维生素D缺乏有关。维生素D作为一种更简单和更易接受的治疗方式,其可能通过维生素D受体调节神经活动,维持神经细胞Ca^2+平衡,减少炎症因子的表达,维持线粒体正常功能,并参与5-羟色胺的合成和活性氧稳态的调节,来实现预防和减轻抑郁的作用。本文就维生素D在改善抑郁中的可能作用机制及其缺乏与抑郁的关系进行综述。

Depression is widespread worldwide,leading to increased mortality and a decline in quality of life.There is growing evidence that depression may be associated with vitamin D deficiency.As a simpler and more acceptable pharmacological intervention,vitamin D may regulate nerve activity through vitamin D receptor,maintain the Ca^2+balance of nerve cells,reduce the expression of inflammatory factors,and maintain the normal function of mitochondria.It also participates in the synthesis of serotonin and the regulation of reactive oxygen homeostasis to prevent and alleviate depression.This article reviews the possible mechanism of vitamin D in improving depression and the relationship between vitamin D deficiency and depression.