13例Cronkhite-Canada综合征临床诊治分析

Clinical diagnosis and treatment of 13 cases of Cronkhite-Canada syndrome

背景Cronkhite-Canada综合征(cronkhitecanadasyndrome,CCS)为临床罕见病,临床多见个案报道,极易漏诊.目前治疗主要以对症治疗为主.通过对13例患者的临床特点及治疗进行回顾性分析,以期提高临床诊断率及临床疗效.目的分析CCS的临床特点.方法回顾性对天津中医药大学第一附属医院及中国人民解放军总医院消化科2000-01/2018-10收治的13名患者的临床资料进行分析.结果13例CCS患者以外胚层变化、胃肠道多发性息肉为主要临床特点,糖皮质激素、粪微生态制品移植及中药治疗有效.结论CCS发病率低,确诊有赖于内镜及组织学检查及典型临床表现,目前国内外尚无统一治疗方案.

BACKGROUND Cronkhite-Canada syndrome (CCS) is a clinically rare disease, which is only sporadically reported and susceptible to missed diagnosis. Current treatment for CCS is mainly symptomatic treatment. AIM To analyze the clinical characteristics of CCS. METHODS The clinical data of 13 patients admitted to the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and Chinese PLA General Hospital from January 2000 to October 2018 were analyzed retrospectively. RESULTS Ectodermal changes and multiple gastrointestinal polyps were the main clinical features of 13 CCS patients. Glucocorticoids, fecal bacteria transplantation, and Chinese herbs were effective. CONCLUSION The incidence of CCS is low, and the diagnosis of CCS relies on endoscopic and histological examinations and typical clinical manifestations. Glucocorticoids, fecal micro-ecological products, and Chinese herbs are effective. Currently, there is no unified treatment scheme for this rare disease.