摘要
葡萄糖抑制的分裂蛋白A(GidA)是一种tRNA修饰酶,在原核生物和真核生物中都非常保守,参与对tRNA的摇摆碱基尿嘧啶进行修饰,然后解码以腺嘌呤或鸟嘌呤结尾的密码子。GidA的这种修饰作用对蛋白质的精确解码和高效翻译至关重要。近年来,对GidA在细胞中的功能研究较多,发现GidA不仅调控细胞的形态还与致病性密切相关,而该蛋白在人类中的同源蛋白MTO1的突变与心肌病变、呼吸障碍、癫痫等多种疾病相关。作者查阅了相关资料,对GidA功能与结构的研究进行综述,以期为了解病原菌的致病机制与人类相关疾病的发病机理提供参考。
GidA-like proteins are tRNA modification enzyme,widely distributed in nature and conserved among bacteria and Eukarya.GidA involves in the addition of the carboxymethylaminomethyl(cmnm) group in position 5 of the U34 of tRNAs that read codons ending with A or G.This modification at the wobble position of the anticodon contributes to the accuracy and efficiency of protein synthesis.Recent years,more and more research focused on cell function of GidA.GidA not only regulates morphology but also pathogenicity in several bacteria.Human mutations of the gidA homologous gene,MTO1,are often associated with hypertrophic cardiomyopathy,respiratory defect,seizures.Through consulting literature materials,we summarized the function and structure of GidA.We hope this review about GidA-like proteins could help in understanding the pathogenesis of pathogenic bacteria and related human diseases.
作者
高婷
袁芳艳
刘泽文
刘威
周丹娜
杨克礼
段正赢
郭锐
梁婉
田永祥
GAO Ting;YUAN Fang-yan;LIU Ze-wen;LIU Wei;ZHOU Dan-na;YANG Ke-li;DUAN Zheng-ying;GUO Rui;LIANG Wan;TIAN Yong-xiang(Institute of Animal Husbandry and Veterinary Medicine,Hubei Acadamy of Agricalture Science/Key Laboratory ofPrevention and Control Agents for Animal Bacteriosis,Wuhan,Hubei,430064,China)
出处
《动物医学进展》
北大核心
2019年第5期98-101,共4页
Progress In Veterinary Medicine
基金
国家重点研发计划项目(2017YFD0500201)
国家自然科学基金青年基金项目(31802189)
农业部畜禽细菌病防治制剂创制重点实验室青年人才基金项目(KLPCAAB-YTP-1802)
湖北省农业科学院青年科学基金项目(2018NKYJJ11)