血浆同型半胱氨酸水平与缺血性脑血管病的关系研究

Correlation study of homocysteine with ischemic cerebrovascular disease

目的:探讨缺血性脑血管病与血浆Hcy水平的关系。方法:选取240例缺血性脑血管病患者,据其影像学特点及临床症状体征分为脑梗死组、短暂性脑缺血发作(TIA)组,同时选择100例同期除外缺血性脑血管病患者作为对照组,采用酶联免疫吸附法检测血浆Hcy水平。结果:缺血性脑血管病组血浆Hcy水平均高于对照组(P<0.05);缺血性脑血管病组高血压病、高甘油三脂血症、糖尿病、烟酒嗜好比例均高于对照组(P<0.05);多因素Logistic回归分析结果显示,高血压、血浆Hcy及高甘油三酯血症为缺血性脑血管病的独立因素。结论:Hcy水平与缺血性脑血管病的临床表现及类型无关,但其水平升高可能是缺血性脑血管病的独立危险因素。

Objective:To study the correlation of ischemic cerebrovascular disease(ICVD) with homocysteine(HCY). Methods: 240 ICVD patients treated in hospital were selected and assigned to cerebral infraction group and transient ischemic attack(TIA) group according to the imaging features and clinical signs. 100 patients without ICVD were selected as control group. The enzyme-linked immunosorbent assay was used to detect the HCY levels.Results: The HCY levels in ICVD patients were significantly higher than control group(P<0.05);the incidence rate of hypertension, hypertriglyceridemia, diabetes mellitus and smoking-alcohol abuse in ICVD patients was significantly higher than control group(P< 0.05);according to the multivariate Logistic regression analysis,it was known that the independent factors of ICVD included the hypertension, HCY and hypertriglyceridemia.Conclusion: The HCY levels have no correlation with the clinical manifestations and classifications of ICVD, but its increased values may become an independent risk factor of ICVD.