化瘀解毒汤配合溻渍法治疗2型糖尿病合并下肢丹毒的临床观察

Clinical observation of HuaYuJieDu decoction combined with wet compress in treating type 2 diabetes complicated with lower limb erysipelas

目的:观察化瘀解毒汤配合溻渍法治疗2型糖尿病合并下肢丹毒的临床疗效。方法:选择60例2型糖尿病合并下肢丹毒的病人,随机分为治疗组和对照组,每组各30例。所有病人均糖尿病饮食、运动及药物血糖控制,对照组给予黄连解毒汤内服配合硫酸镁湿敷,治疗组给予化瘀解毒汤内服,配合中医溻渍法外用给药,内服药相同煎煮方法,早晚分服,外治法每次30 min,每日更换2次,疗程14 d。观察2组体温、白细胞(WBC)、中性粒细胞百分比(N%)、C反应蛋白(CRP)水平及疗效等。结果:2组治疗前后空腹血糖(FPG)、丙氨酸氨基转移酶(ALT)、肌酐(Cr)水平差异均无统计学意义(P>0.05)。2组治疗前后体温、WBC、N%、CRP及治疗后体温差异均无统计学意义(P>0.05);2组治疗后WBC、N%、CRP水平均较治疗前变化明显(P<0.01);且治疗后WBC、N%、CRP水平均有统计学意义(P<0.01)。治疗组有效率为93.33%,优于对照组的80.00%(P<0.05)。结论:化瘀解毒汤配合溻渍法可明显改善2型糖尿病合并下肢丹毒临床症状,控制病人体温及炎症情况,效果优于黄连解毒汤配合硫酸镁湿敷,且具有良好安全性。

Objective:To observe the clinical effects of Huayu Jiedu decoction combined with wet compress in treating type 2 diabetes complicated with lower limb erysipelas. Methods:Sixty patients with type 2 diabetes complicated with lower limb erysipelas were randomly divided into the control group and treatment group(30 cases each group). All patients were treated with diabetic diet,exercise and drug to control the blood glucose. The control group was treated with HuangLianJieDu decoction by oral combined with wet compress of magnesium sulfate,and the treatment group was treated with Huayu Jiedu decoction by oral combined with wet compress of traditional Chinese medicine. The process method of oral decoction in two groups was the same,and the decoction was orally taken in the morning and evening. The wet compress in two groups was given twice a day,30 min/ time,for 14 days. The levels of body temperature,white blood cell(WBC),neutrophil percentage(N%),C reactive protein(CRP),and curative effect in two groups were observed. Results: Before and after treatment,the differences of the levels of FPG,ALT and Cr between two groups were not statistically significant(P > 0. 05). The difference of the levels of body temperature,WBC,N% and CRP before and after treatment,and temperature after treatment between two groups were not statistically significant(P >0. 05). The levels of WBC,N% and CRP in two groups after treatment changed significantly compared with before treatment(P < 0. 01),and the differences of WBC,N% and CRP level after treatment were statistically significant(P <0. 01). The effective rate in treatment group was 93. 99%,which was significantly better than that in control group(80. 00%)(P <0. 05). Conclusions:Huayu Jiedu decoction combined with wet compress can significantly improve the clinical symptoms of type 2 diabetes complicated with lower limb erysipelas,control the body temperature,and reduce the inflammation,and has good safety. The clinical effect of which is better than that of Huanglian JieDu decoction combine with magnesium sulfate wet compress, and safe.