幽门螺杆菌感染对同型半胱氨酸及血脂的影响探讨

Investigation of the influence of Helicobacter pylori infection on the levels of homocysteine and blood lipid

目的:探讨幽门螺杆菌(Helicobacter pylori,HP)感染对同型半胱氨酸(homocysteine,Hcy)及血脂的影响。方法:选取102例住院病人,根据有无HP感染情况将其分为HP感染组和HP未感染组,分别测定2组Hcy水平、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的水平,分析HP感染对Hcy及血脂水平的影响以及相关性。结果:HP感染组高同型半胱氨酸血症(HHcy)检出率为19.61%(10/51),高于HP未感染组的5.88%(3/51)(P<0.05); HP感染组的TC、HDL-C、LDL-C异常检测率均高于HP未感染组(P<0.05～P<0.01)。HP感染组病人血清TC、TG的水平均高于HP未感染组,但差异无统计学意义(P>0.05);HP感染组的Hcy和LDL-C水平均高于HP未感染组(P<0.05),而HDL-C水平低于HP未感染组(P<0.05)。HP抗体水平与病人体内的Hcy、TC、LDL-C水平呈正相关关系(r=0.248、0.243和0.272,P<0.05)。结论:HP感染与HHcy的发生及血脂水平的异常密切相关,并能增加心血管疾病的风险。

Objective:To explore the influence of Helicobacter pylori(HP) infection on the levels of homocysteine(Hcy) and blood lipid. Methods:One hundred and two hospitalized patients were divided into the HP infection group and HP uninfection group according to the HP infection situation, respectively. The levels of Hcy, total cholesterol ( TC), triglyceride ( TG), high-density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C),were detected in two groups. The influence of HP infection on the levels of Hcy and blood lipid between two groups was compared,and the correlation between the level of Hcy and blood lipid was analyzed in two groups. Results:The detection rates of HHcy in HP infection group and HP uninfection group were 19. 61%(10/51) and 5. 88%(3/51),respectively,and the difference of which was statistically significant(P < 0. 05). The abnormal detection rates of the levels of TC,HDL-C and LDL-C in HP infection group were higher than those in HP uninfection group(P <0. 05 to P <0. 01). The levels of TC and TG in HP infection group were higher compared with the HP uninfection group,and the difference of which was not statistically significant(P >0. 05). The levels of Hcy and LDL-C in HP infection group were higher than those in HP uninfection group (P <0. 05). The level of HDL-C in HP infection group was lower than that in HP uninfection group(P <0. 05). HP antibody level was positively correlated with the levels of Hcy,TC and LDL-C(P <0. 05). Conclusions:HP infection is closely related to the occurrence of HHcy,and the abnormal level of blood lipid,can lead to the risk increasing of cardiovascular disease.