氧化应激在脓毒症器官功能损伤中的作用

Role of oxidative stress in organ dysfunction of sepsis

脓毒症是因宿主对感染的反应失调而导致的危及生命的器官功能障碍,是临床急危重症患者的严重并发症,可进展为重症脓毒症、感染性休克,最终导致死亡。氧化应激作为脓毒症进展为重度脓毒症、感染性休克的重要原因,近年受到重视。本文对脓毒症时氧化应激在人体器官功能损伤中的作用机制作一综述。

Sepsis is a life-threatening organ dysfunction caused by the host's imbalance of response to infection.It is a serious complication of clinical critical patients.Sepsis can progress to severe sepsis,and septic shock eventually leads to death.Various mechanisms are involved in the occurrence and development of sepsis.Oxidative stress,as a major cause of sepsis and septic shock,has been paid more and more attention in recent years.This article reviews the mechanism of oxidative stress in the damage of human organ function in sepsis.