摘要
近年来,介孔硅纳米粒子(MSNs)因其独特的优良性能而被广泛应用于构建各种智能型药物递送系统。这种基于介孔硅纳米粒子的各种刺激响应型药物递送系统能有效负载抗癌药物,并将其靶向运输到肿瘤部位且内化进入肿瘤细胞,然后在特异性刺激信号的作用下响应性释放抗癌药物。这种将抗癌药物特异性递送至靶位点的方式,不仅能极大程度上发挥药物疗效,还能有效降低抗癌药物对健康组织器官的毒副作用,从而提高抗癌药物在肿瘤治疗中的优势。对多种刺激响应型介孔硅纳米药物递送系统在肿瘤治疗中的应用及发展作一综述。
In recent years, mesoporous silica nanoparticles (MSNs) have been widely used in the construction of various intelligent drug delivery systems due to their unique and excellent properties. The stimuli-responsive drug delivery system based on mesoporous silica nanoparticles can effectively load anticancer drugs and target them to tumor cells, and then responsively release anticancer drugs under the action of specific stimulation signals. The method of specifically delivering anticancer drugs to target sites not only can greatly improvethe drug efficacy, but also effectively reduce the side effects of anticancer drugs on normal tissues and organs. Thereby the advantages of anticancer drugs in tumor therapy are improved. In this paper, the applications and developments of stimuli-responsive mesoporous silica nano drug delivery systems in tumor therapy were summarized.
作者
黄晨露
朱敦皖
张琳华
Huang Chenlu;Zhu Dunwan;Zhang Linhua(Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Biomedical Materials, Tianjin 300192, China)
出处
《国际生物医学工程杂志》
CAS
2019年第1期66-70,共5页
International Journal of Biomedical Engineering
基金
国家自然科学基金面上项目(81571793,81671806)
中国医学科学院医学与健康科技创新工程(2017-I2M-4-001,2017-I2M-3-020)
天津市自然科学基金重点项目(15JCZDJC38300).
关键词
介孔硅纳米粒子
刺激响应型
控制释放
肿瘤治疗
Mesoporous silica nanoparticles
Stimuli-responsive
Controlled release
Tumor therapy
