小剂量强的松联合中波窄谱紫外线和复方白芷酊治疗进展期泛发型白癜风的临床观察

Clinical observation of low-dose prednisone combined with NB-UVB and compound angelica officinalis tincture in the treatment of progressive general vitiligo

目的观察小剂量强的松片联合中波窄谱紫外线和复方白芷酊治疗进展期泛发型白癜风的临床疗效。方法56例进展期泛发型白癜风患者随机分为治疗组和对照组,每组28例。治疗组采用小剂量强的松联合中波窄谱紫外线和复方白芷酊治疗;对照组采用中波窄谱紫外线联合复方白芷酊治疗,均连续治疗24周。观察及对比两组治疗12、24周的疗效及治疗期间的不良反应。结果两组治疗12周疗效的差异无统计学意义(P>0.05)。治疗24周,治疗组的疗效优于对照组(P<0.05)。两组治疗过程中均未发生明显的不良反应。结论小剂量强的松联合中波窄谱紫外线和复方白芷酊治疗进展期泛发型白癜风疗效显著,安全,值得临床推广。

Objective To investigate the clinical effect of low-dose prednisone combined with NB-UVB and compound angelica officinalis tincture in the treatment of progressive general vitiligo.Methods A total of 56 cases with vitiligo were enrolled in the study and randomly divided into the Treatment Group and Control Group,28 cases in each group.The Treatment Group was administered with 10mg-15mg prednisone combined with NB-UVB and topical compound angelica officinalis tincture for 24 weeks while the control group was treated with NB-UVB combined with compound angelica officinalis tincture for 24 weeks.Results After 12-week treatment,there was no statistical difference between the two groups (P>0.05).After 24-week treatment,the total effective rate of the Treatment Group was significantly higher than that of the Control Group (P<0.05).There was no significant adverse reaction in both groups during the treatment.Conclusion The low-dose prednisone combined with NB-UVB and compound angelica officinalis tincture has significant effect and is safe in the treatment of progressive general vitiligo,and it is worth clinical promotion.