自血穴位注射疗法联合马来酸茚达特罗治疗老年稳定期慢性阻塞性肺疾病的临床分析

Clinical efficacy of autoblood acupoint-injection therapy combined with indacaterol maleate on elderly patients with chronic obstructive pulmonary disease in stable phase

目的探讨自血穴位注射疗法联合马来酸茚达特罗治疗老年稳定期慢性阻塞性肺疾病(COPD)的临床疗效及其对患者炎性因子、免疫功能及肺功能的影响。方法将2015年5月至2016年5月我院收治的86例老年缓解期COPD患者分为观察组与对照组。对照组给予马来酸茚达特罗治疗,观察组在对照组治疗基础上另给予自血穴位注射疗法。治疗12周后,评价2组临床疗效。治疗前及治疗12周后,分别检测2组患者肺功能指标(FEV_1、FVC与PEF),炎性因子(IL-8、α1-AT、IL-6及TNF-α),免疫功能指标(Ig G、Ig A、CD3^+及CD4^+)水平。治疗期间,对2组患者的不良反应进行密切观察。结果治疗后二组患者各项检测指标均优于治疗前。治疗12周后,观察组总有效率为90.7%,明显高于对照组的72.1%(P<0.05)。治疗12周后,观察组FEV_1、FVC与PEF等肺功能指标,Ig G、Ig A、CD3^+及CD4^+等免疫功能指标水平均明显高于对照组(P<0.05),而IL-8、α1-AT、IL-6及TNF-α含量分别为(23.23±3.87)ng/L、(3.43±0.41) g/L、(52.25±5.38) ng/L及(43.12±3.98) ng/L,改善程度均明显优于对照组(P<0.05)。治疗期间,2组患者均未出现严重不良反应。结论自血穴位注射疗法联合马来酸茚达特罗治疗老年稳定期COPD疗效确切,可有效改善患者炎症水平,值得进行深入研究。

Objective To explore the clinical efficacy of autoblood acupoint-injection therapy combined with indacaterol maleate on the elderly patients with chronic obstructive pulmonary disease(COPD)in the stable phase and its influence on the levels of inflammation index,immune function index and lung function index.Methods A total of 86 elderly COPD patients in the stable phase treated in our hospital from May 2015 to May 2016 were divided into an observation group and a control group.The control group was given indacaterol maleate,while the treatment group was treated with indacaterol maleate and autoblood acupoint-injection therapy.Before treatment and 12 weeks after treatment,the levels of lung function index(FEV 1,FVC and PEF),inflammation index(IL-8,α1-AT,IL-6 and TNF-α),and immune function index(IgG,IgA,CD3+and CD4+)were detected and compared between the two groups.The adverse reactions in the two groups were also observed.Results At 12 weeks after treatment,the total effective rate was 90.7%in the treatment group,which was significantly higher than that of the control group(70.2%,P<0.05).And 12 weeks after treatment,the levels of lung function index(including FEV 1,FVC and PEF)and immune function index(containing IgG,IgA,CD3+and CD4+)in the treatment group were significantly higher than those of the control group(P<0.05),while the levels of IL-8,α1-AT,IL-6 and TNF-αwere(23.23±3.87)ng/L,(3.43±0.41)g/L,(52.25±5.38)ng/L and(43.12±3.98)ng/L,respectively,which were significantly lower than those of the control group(P<0.05).There were no serious adverse reactions in the two groups.Conclusion The curative effect of autoblood acupoint-injection therapy combined with indacaterol maleate on the elderly COPD patients in the stable phase is affirmative,which can ameliorate the inflammation status of the patients.