妊娠晚期孕妇GBS带菌状况对妊娠结局及其新生儿预后的影响

Effect of GBS-bearing Status in Pregnant Women on Pregnancy Outcome and Prognosis of Neonates

目的:探讨妊娠晚期孕妇B族溶血性链球菌(B group hemolytic streptococcus,GBS)带菌状况对妊娠结局及其新生儿预后的影响。方法:选择2015年6月-2017年6月于本院确诊GBS带菌的孕晚期孕妇48例纳入治疗组,根据其药敏实验结果对治疗组孕妇行针对性治疗。同期未感染GBS的孕晚期孕妇47例纳入空白组。而后回顾性分析2015年9月-2016年9月于本院行产检并确诊GBS带菌但未进行干预措施的孕晚期孕妇病历49例,纳入未治疗组。比较三组妊娠结局、妊娠期间不良反应以及新生儿出生后情况之间的差异。结果:未治疗组早产、胎膜早破及剖宫产发生率高于其他两组,差异均有统计学意义(P<0.05);未治疗组宫内感染及产褥感染发生率高于其他两组,差异均有统计学意义(P<0.05),三组患者产后出血及迟发性产后出血发生率比较,差异均无统计学意义(P>0.05);未治疗组分娩后的新生儿感染、胎儿生长受限及新生儿窒息发生率高于其他两组,差异均有统计学意义(P<0.05);三组分娩后新生儿病理性黄疸发生率比较,差异均无统计学意义(P>0.05)。结论:GBS会导致孕妇不良妊娠结局的同时引起分娩后相关新生儿疾病发生概率上升,通过有效的抗生素治疗能显著改善孕妇妊娠结局及新生儿出生后情况。

Objective:To investigate the effects of GBS on the pregnancy outcome and the prognosis of neonates in pregnant women.Method:A total of 48 pregnant women in the third trimester diagnosed with GBS in our hospital from June 2015 to June 2017 were enrolled in the treatment group.According to the results of drug susceptibility test,the treatment group was treated with targeted treatment.47 pregnant women in the third trimester not infected with GBS during the same period were included in the blank group.Then,retrospective analysis of 49 cases of pregnant women in the third trimester of pregnancy from September 2015 to September 2016 in our hospital and confirmed the diagnosis of GBS,but was did not received any intervention measures and were included in the untreated group.The pregnancy outcomes,adverse reactions during pregnancy,and conditions of neonates after birth between the three groups were compared.Result:The incidence of premature delivery,premature rupture of membranes and cesarean section in the untreated group were higher than those in the other two groups,the differences were statistically significant(P<0.05).The incidence of intrauterine infection and puerperal infection in the untreated group were higher than those in the other two groups,the differences were statistically significant (P<0.05).There was no significant difference in the incidence of postpartum hemorrhage and delayed postpartum hemorrhage between the three groups(P>0.05).The incidence of neonatal infection,fetal growth restriction and neonatal asphyxia in the untreated group were higher than the other two groups,the differences were statistically significant(P<0.05).There was no significant difference in the pathological jaundice rate between the three groups after delivery(P>0.05).Conclusion:GBS can lead to adverse pregnancy outcomes in pregnant women,and the incidence of related neonatal diseases increases after delivery.Effective antibiotic treatment can significantly improve pregnancy outcomes and postnatal neonatal conditions.