精蛋白锌重组赖脯胰岛素与精蛋白重组人胰岛素治疗初诊2型糖尿病的疗效、安全性及成本分析研究

Comparison on Efficacy,Safety and Cost of Mixed Protamine Zinc Recombinant Human Insulin Lispro Injection and Premixed Protamine Recombinant Human Insulin Injection in Treatment of Newly Diagnosed Type 2 Diabetes

目的:比较精蛋白锌重组赖脯胰岛素混合注射液与精蛋白重组人胰岛素混合注射液在治疗2型糖尿病中的临床疗效、安全性和成本。方法:选取2015年6月-2018年2月本院门诊收治的初诊2型糖尿病患者60例。按照随机数字表法将其分为A组和B组,各30例。A组接受精蛋白重组人胰岛素混合注射液早晚两针注射治疗,B组接受精蛋白锌重组赖脯胰岛素混合注射液早晚两针注射治疗。12周结束后,比较两组患者治疗前后血糖控制情况、低血糖发生率、体重和治疗成本等。结果:治疗后,B组空腹及餐后2 h血糖、HbA1c水平均低于A组,差异均有统计学意义(P<0.05);B组低血糖发生率为3.3%,低于A组的20.0%(P<0.05);治疗前后,两组体重及增幅比较,差异均无统计学意义(P>0.05);B组胰岛素每日用量低于A组,但胰岛素费用及总费用均高于A组,差异均有统计学意义(P<0.05)。结论:精蛋白锌重组赖脯胰岛素混合注射液治疗效果更佳,低血糖的发生率也较低,同时夜间无低血糖发生,体重增加无明显差异,使用方便,但治疗费用更高。

Objective:To compare and observe the efficacy,safety and cost of Mixed Protamine Zinc Recombinant Human Insulin Lispro Injection and Premixed Protamine Recombinant Human Insulin Injection in treatment of newly diagnosed type 2 diabetes.Method:A total of 60 patients with newly diagnosed type 2 diabetes admitted to our hospital from June 2015 to February 2018 were selected.According to the random number table method,they were divided into A group and B group,30 cases in each group.A group received two injections of premixed protamine recombinant human insulin injection in the morning and evening,B group received two injections of mixed protamine Zinc recombinant human insulin lispro injection in the morning and evening.After 12 weeks,blood sugar control,incidence of hypoglycemia,body weight and treatment cost were compared between two groups before and after treatment.Result:After treatment,the fasting and 2 h postprandial blood sugar and HbA1c levels in B group were lower than those of A group,the differences were statistically significant (P<0.05).The incidence of hypoglycemia in B group was 3.3%,lower than 20.0% in A group(P<0.05). Before and after treatment,the body weight and growth rate of two groups were compared,the differences were not statistically significant(P>0.05).The daily dosage of insulin in B group was lower than that of A group,but the insulin cost and total cost of in B group were higher than those of A group,the differences were statistically significant(P<0.05).Conclusion:Mixed protamine Zinc recombinant human insulin lispro injection has better therapeutic effect,lower incidence of hypoglycemia,no hypoglycemia at night,no significant difference in weight gain,easy to use,but higher treatment costs.