载药微球栓塞治疗肝癌的临床效果

Clinical Effect of Drug-loaded Microsphere Embolization in the Treatment of Hepatocellular Carcinoma

目的:探讨采取载药栓塞微球介入治疗肝癌的临床效果。方法:选取2017年1月-2018年6月本院接收的60例转移性肝癌患者,将患者按照随机数字表法分为对照组与观察组,各30例。对照组采取单纯的碘化油栓塞治疗,观察组采取载药栓塞微球介入治疗。对两组患者的临床效果及相关指标进行观察比较。结果:观察组患者临床总有效率明显高于对照组,差异有统计学意义(P<0.05)。术后1个月,两组患者血清肿瘤标志物均低于术前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。观察组PFS明显长于对照组,差异有统计学意义(P<0.05)。术后3 d,两组患者的谷丙转氨酶和谷草转氨酶均高于术前,差异均有统计学意义(P<0.05);但观察组肝功能基本在术后3个月时恢复至术前水平且低于对照组,而对照组术后3个月的谷丙转氨酶和谷草转氨酶均较高,差异均有统计学意义(P<0.05)。观察组患者的呕吐、腹痛、发热、肝区疼痛发生率均明显低于对照组,差异均有统计学意义(P<0.05)。术后1个月,观察组患者QOL评分明显高于对照组,EOCG评分明显低于对照组,差异均有统计学意义(P<0.05)。结论:转移性肝癌采取载药栓塞微球治疗,效果显著,能提高患者的生存质量,不良反应小,具有临床推广价值。

Objective:To investigate the clinical effect of drug-loaded microsphere embolization in the treatment of hepatocellular carcinoma.Method:60 metastatic hepatic carcinoma patients treated from January 2017 to June 2018 in our hospital were selected,patients were divided into control group and observation group according to the random number table method,30 cases in each group.The control group took the embolization therapy with iodinated oil;the observation group took the intervention therapy with drug-loaded microsphere embolization.The clinical effect and relative indexes of the two groups were observed and compared.Result:The total effective rate in the observation group was significantly higher than that in control group,the difference was statistically significant(P<0.05).1 month after surgery,serum tumor markers in both groups were lower than those before surgery,and those in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The PFS of the observation group was significantly longer than that of the control group,the difference was statistically significant(P<0.05).Three days after surgery,alanine aminotransferase and cereal grass aminotransferase in both groups were higher than those before surgery,and the differences were statistically significant(P<0.05);however,the liver function of the observation group basically recovered to the preoperative level at 3 months after surgery and was lower than those of the control group,while the levels of alanine transaminase and oryza transaminase in the control group were higher at 3 months after surgery,and the differences were statistically significant(P<0.05).The incidence of vomiting,abdominal pain,fever and liver pain in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).1 month after surgery,QOL score in the observation group was significantly higher than that in the control group,and EOCG score was significantly lower than that in the control group,with statistically significant differences(P<0.05).Conclusion:The embolization therapy with drug-eluting beads can remarkably increase the clinical effect and quality of life,and reduce the adverse event rate,it is worthy of clinical promotion.