曲普瑞林联合高强度聚焦超声消融治疗子宫腺肌病的疗效观察

An observation of the efficacy of triptorelin combined with high intensity focused ultrasound for treating women with adenomyosis

目的:探讨曲普瑞林联合高强度聚焦超声消融治疗子宫腺肌病的疗效观察。方法:将68例子宫腺肌病患者分为观察组和对照组。观察组在术前采用曲普瑞林治疗,两组均给予高强度聚焦超声消融治疗。彩色超声检测治疗前后病灶和子宫体积。统计月经量。采用视觉模拟评分法(VAS)评估痛经程度,子宫腺肌病症状及健康相关生活质量问卷(UFS-QOL)评估生存质量,观察复发及妊娠情况。结果:治疗后观察组总有效率高于对照组,病灶体积、子宫体积观察组低于对照组低(均P<0.05);痛经评分、月经量评分、UFS-QOL评分两组均降低,观察组低于对照组低,复发率观察组低于对照组低(均P<0.05);两组妊娠率对比无差异(P>0.05)。结论:曲普瑞林联合高强度聚焦超声消融治疗子宫腺肌病疗效确切,能减轻痛经程度,减少月经量,改善生存质量。

Objective:To investigate the efficacy of triptorelin combined with high intensity focused ultrasound for treating women with adenomyosis.Methods:68 patients with adenomyosis were divided into study group and control group.The women in control group were treated by high intensity focused ultrasound,and the women in study group were treated by high intensity focused ultrasound combined with triptorelin before operation.Color Doppler ultrasound was used to detect the volumes of uterus and uterine lesion of before and after treatment.The volumes of menstruation of all included women were recorded,and the dysmenorrhea degree was assessed by visual analogue scale (VAS).The quality of life of women in the two groups was assessed by adenomyosis symptoms and health related quality of life questionnaire (UFS QOL).The rates of recurrence and pregnancy of women in the two groups were observed.Results:After treatment,the total effective rate of women in study group was significant higher than that of women in control group,and the volumes of uterus and uterine lesion were significant smaller than those of women in control group (P <0.05).After treatment,the scores of dysmenorrhea,menstrual volume,and UFS QOL of women in the two groups decreased significantly (P <0.05),and those of women in study group were significant lower than those of women in control group (P <0.05).The recurrence rate of women in study group was also significant lower (P < 0.05).Conclusion:Triptorelin combined with high intensity focused ultrasound is effective for treating women with adenomyosis,which can relieve dysmenorrhea,reduce menstruation volume,and improve the quality of life.