地屈孕酮、黄体酮不同支持方案对先兆流产患者妊娠结局的影响

The influence of dydrogesterone or progesterone for treating women with threatened abortion on the pregnancy outcomes

目的:探讨地屈孕酮、黄体酮不同支持方案对先兆流产患者妊娠结局的影响。方法:以2017年2月—2018年2月本院收治的82例先兆流产患者为研究对象,采用随机数字表法将其分为对照组和观察组各41例,对照组实施地屈孕酮支持方案治疗,观察组实施黄体酮支持方案治疗,比较两组临床疗效,观察治疗前后两组激素[血清孕酮(P)、β-人绒毛膜促性腺激素(β-hCG)]水平变化、妊娠结局及药物安全性。结果:治疗后临床总有效率观察组与对照组未见差异(P>0.05); P、β-hCG治疗前两组比较无差异(P>0.05),治疗后两组均升高(P<0.05),但两组间无差异(P>0.05);治疗后保胎成功率观察组与对照组无差异(P>0.05),不良反应总发生率观察组低于对照组(P<0.05)。结论:地屈孕酮、黄体酮两种不同支持方案对先兆流产患者临床治疗效、调节激素水平和改善妊娠结局方面效果相当,但黄体酮治疗方案在药物安全性方面更优。

Objective:To investigate the influence of different regimens of dydrogesterone or progesterone for treating women with threatened abortion on pregnancy outcomes.Methods:82 women with threatened abortion were selected as study subjects from February 2017 to February 2018,and were randomly divided into control group and observation group (41 cases in each group) according to random numbers table.The women in control group were treated by dydrogesterone,and the women in observation group were treated by progesterone.The clinical curative effect of women was compared between the two groups.The changes of levels of serum progesterone (P) and β human chorionic gonadotropin (β hCG),pregnancy outcomes,and drug safety of women in both groups were observed before and after treatment.Results:The overall curative effect of women had no significant different between the two groups (P > 0.05).There was no significant different in levels of P and β hCG between the two groups before and after treatment (P >0.05),but the levels of P and β hCG of women in both groups were significantly increased after treatment (P < 0.05).The rate of continually pregnancy of women in observation group had no significant different that of women in control group (P >0.05).The total incidence of adverse reactions of women in observation group was significant lower than that of women in control group (P <0.05).Conclusion:Dydrogesterone and progesterone are similar efficacy for treating women with threatened abortion,which can regulate hormone and improve the pregnancy outcomes.However,progesterone has more advantages in terms of drug safety,so it is worthy of clinical application.