老年女性高血压患者氧化低密度脂蛋白水平及相关影响因素分析

Serum ox-LDL level and its influencing factors in elderly female hypertension patients

目的探讨老年女性高血压患者氧化低密度脂蛋白(ox-LDL)水平及相关影响因素分析。方法回顾性分析290例女性体检人群,根据是否有高血压,分为高血压组96例和非高血压组194例,收集2组一般资料;将高血压组进一步根据年龄分成老年组47例(≥60岁)和非老年组49例(<60岁),比较2组临床特征;分析ox-LDL的影响因素。结果高血压组年龄、收缩压、舒张压、空腹血糖、ox-LDL、脂蛋白相关磷脂酶A2(Lp-PLA2)、TC、LDL-C、体质量指数、糖尿病及冠心病比例明显高于非高血压组,差异有统计学意义(P<0.05,P<0.01)。老年组年龄、收缩压、空腹血糖、ox-LDL、Lp-PLA2、TC、LDL-C及冠心病比例明显高于非老年组(P<0.05,P<0.01),舒张压明显低于非老年组[(80.72±9.32)mm Hg(1mm Hg=0.133kPa)vs (86.69±10.27)mm Hg,P=0.004]。ox-LDL水平与年龄、收缩压、舒张压、空腹血糖、肌酐、TC、LDL-C、TG、Lp-PLA2及吸烟呈正相关(P<0.05,P<0.01)。回归分析显示,TC、Lp-PLA2、LDL-C、舒张压是女性高血压患者ox-LDL的危险因素(P<0.05,P<0.01)。结论老年女性高血压患者ox-LDL水平显著升高,TC、Lp-PLA2、LDL-C、舒张压是高血压患者ox-LDL的影响因素。

Objective To study the serum ox-LDL level and its influencing factors in elderly female hypertension patients.Methods Two hundred and ninety elderly females were divided into hypertension group(n=96)and hypertension-free group(n=194).Their age and blood routine examination data were recorded.The patients in hypertension group were further divided into≥60 years old group(n=47)and<60 years old group(n=49),their clinical characteristics were compared. The influencing factors of ox-LDL were analyzed.Results The age was significantly older, the SBP and DBP,serum FBG,ox-LDL,Lp-PLA2,TC,LDL-C levels,BMI,incidence of DM and CHD were significantly higher in hypertension group than in hypertension-free group(P<0.05, P<0.01).The age was significantly older,the SBP,serum FPG,ox-LDL,Lp-PLA2,TC,LDL-C levels and incidence of CHD were significantly higher while the DBP was significantly lower in≥60 years old group than in<60 years old group(P<0.05,P<0.01).Serum ox-LDL level was positively related with age,SBP,DBP,serum FPG,creatinine,TC,LDL-C,Lp-PLA2 levels and smoking(P<0.05,P<0.01).Multivariate linear regression analysis showed that serum TC, Lp-PLA2,LDL-C levels and DBP were the risk factors for ox-LDL in female hypertension patients (P<0.05,P<0.01).Conclusion The serum ox-LDL level is significantly higher in elderly female hypertension patients than in elderly male hypertension patients.Serum TC,Lp-PLA2,LDL-C levels and DBP are the risk factors for ox-LDL in elderly female hypertension patients.