新型口服抗凝药不良反应研究进展

Adverse Reactions of Novel Oral Anticoagulants

新型口服抗凝药是华法林及其他维生素K拮抗剂的一类替代药物。相较于维生素K拮抗剂,新型口服抗凝药起效快、半衰期短、无需实验室监测、不易受食物及药物影响,主要用于非瓣膜性心房颤动患者缺血性卒中的预防。新型口服抗凝药在临床应用时间较短,报道的最为主要的不良反应为出血,现对近年来涉及新型口服抗凝药主要不良反应的研究进行综述,为临床安全应用提供参考。

Novel oral anticoagulants (NOACs) are alternative medicines for warfarin and other vitamin-K antagonists.NOACs offer potential advantages over VKAs,such as rapid onset of action,short half-life,do not require regular monitoring and fewer drug and food interactions.NOACs are used for the prevention of ischemic stroke in patients with non-valvular atrial fibrillation.NOACs have short application time,and the major adverse reaction reported is gastric hemorrhage.This article reviews recent studies on the adverse reaction of NOACs and provides a reference for clinical drug use.