动脉粥样硬化斑块内血管生成的研究进展及治疗策略

Progress and Treatment Strategies of Plaque Angiogenesis in Atherosclerosis

动脉粥样硬化斑块破裂或糜烂引发的急性心血管事件是患者死亡的主要原因。斑块内血管生成是促进斑块生长并造成斑块不稳定的重要因素之一。新生的血管发育不成熟,存在结构和功能的异常,导致反复发生斑块内出血。现从斑块内血管生成促进动脉粥样硬化发展的机制、检测血管生成的影像学方法以及抗血管生成的治疗策略等方面进行综述。

Acute adverse events caused by rupture or erosion of atherosclerotic plaques are the main cause of death in patients with cardiovascular diseases.It is becoming more and more clear that plaque angiogenesis is an important contributor to plaque growth and instability.The vessels’ immaturity,with profound structural and functional abnormalities,leads to recurrent intraplaque hemorrhage.This review focuses on biological mechanisms of plaque angiogenesis in atherosclerosis progression.Moreover,options to target plaque angiogenesis for imaging and therapeutic purposes will be discussed.