深部热疗对胰腺癌免疫功能影响的研究进展

Research progress of deep regional hyperthermia on immunity of pancreatic cancer

胰腺癌是全球最致命的癌症类型之一,由于胰腺特殊的解剖位置及生物学特性,其早期诊断困难,病死率高。晚期胰腺癌多采取综合治疗,深部热疗是其治疗手段之一,目前已联合手术、放疗、化疗、免疫治疗等手段运用于临床实体肿瘤治疗过程中。深部热疗对胰腺癌肿瘤细胞具有直接的杀伤作用,同时对机体免疫系统的影响也较为复杂、广泛,主要表现在对肿瘤微环境、免疫细胞及热休克蛋白等有一定的作用。本文就深部热疗对胰腺癌免疫功能方面的影响进行综述。

Pancreatic cancer is one of the most lethal cancers in the world.Because of its special anatomical location and biological characteristics,pancreatic cancer is difficult to be diagnosed early and has high mortality.Comprehensive treatment is mostly used in advanced pancreatic cancer.Deep regional hyperthermia has been used in the treatment of various solid tumors combined with surgery,radiotherapy,chemotherapy,immunological therapy and others.Hyperthermia can directly kill pancreatic cancer cells.At the same time,it has complicated and extensive influence on the immune system,which is mainly manifested in tumor microenvironment,immune cells,heat shock proteins,et al.This article reviewed the progress of deep regional hyperthermia on immunity of pancreatic cancer.