阿德福韦酯联合拉米夫定对乙肝肝硬化患者的临床作用

Clinical Effect of Adefovir Dipivoxil Combined with Lamivudine on Patients with Hepatitis B Cirrhosis

目的分析乙肝肝硬化患者应用拉米夫定联合阿德福韦酯治疗的临床效果。方法抽取我院收治的乙肝肝硬化患者82例,按数学随机数列表分为对照组和治疗组,每组41例。对照组采用恩替卡韦治疗;治疗组采用拉米夫定联合阿德福韦酯治疗。比较两组乙肝肝硬化疾病药物治疗总有效率、用药后HBV-DNA检测结果转阴例数、药物不良反应例数、肝功能相关指标评分在治疗前后的改善幅度、肝功能指标复常时间和用药总时间。结果治疗组患者治疗总有效率为87.8%,高于对照组的61.0%,差异显著(P<0.05);用药后有34例HBV-DNA检测结果转阴,多于对照组的21例,差异显著(P<0.05);仅有2例出现不良反应,少于对照组的10例,差异显著(P<0.05);肝功能相关指标评分在治疗前后的改善幅度大于对照组,组间差异显著(P<0.05);肝功能指标复常时间和用药总时间短于对照组,组间差异显著(P<0.05)。结论乙肝肝硬化患者采用拉米夫定联合阿德福韦酯治疗可以短时间内改善肝功能,减少药物不良反应,提高疾病治疗总有效率。

Objective To analyze the clinical effect of lamivudine combined with adefovir dipivoxil in the treatment of patients with hepatitis B cirrhosis.Methods 82 cases of patients with hepatitis B liver cirrhosis in our hospital were selected and divided into the control group and the treatment group by the random number list,with an average of 41 cases in each group.The control group was treated with entecavir,and the treatment group was treated with lamivudine and adefovir dipivoxil two drugs.Comparison of two groups of hepatitis B cirrhosis disease total efficiency of treatment,after treatment HBV the results of DNA negative cases,liver function,the number of cases of adverse drug reactions related indicators score in liver function indexes before and after treatment,the improvement of the recovery time and the total time of medication.Results The treatment group with cirrhosis of liver disease drug treatment the total effective rate reached 87.8%,higher than that of the control group 61.0%,significant difference(P<0.05);after treatment of 34 cases of HBV negative DNA results,more than 21 cases in the control group,the difference was significant(P<0.05);only 2 cases of drug adverse reactions lead to the less than 10 cases in the control group,the difference was significant(P<0.05);the relevant indicators of liver function score before and after treatment significantly improved than the control group,significant difference between groups(P<0.05);liver function recovery time and the total treatment time was shorter than the control group,significant difference between groups(P<0.05).Conclusion The treatment of hepatitis B cirrhosis patients with lamivudine combined with adefovir dipivoxil two drugs can improve the liver function in a short period of time,reduce adverse drug reactions,improve the total efficiency of the treatment of the disease.