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药动学中残数法在猪瘟母源抗体持续期及半衰期研究中的应用

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摘要 运用药物动力学理论中的残数法对猪瘟母源抗体中和效价数据进行了代谢动力学研究,通过残数法计算出猪瘟E2亚单位疫苗与传代细胞猪瘟兔化弱毒疫苗免疫母猪后其断奶仔猪的母源抗体中和效价代谢动力学消除常数(k)分别为-0.041511d^(-1)和-0.058923d^(-1),疫苗在仔猪体内的半衰期(t_(1/2))分别为16.69d和11.76d,并分别计算出了不同疫苗的最佳免疫日龄。为新的母源抗体持续期及半衰期研究方法和思路提供理论依据。
出处 《中国猪业》 2019年第4期38-40,共3页 China Swine Industry
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