右美托咪定对COPD患者撤机后镇痛镇静作用分析

Analysis of Analgesic and Sedative Effects of Dexmedetomidine on Patients With COPD After Weaning

目的探析右美托咪定对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者撤机后镇痛镇静作用。方法选用2017年1月—2018年9月经本院收治的成功撤机(> 12 h)COPD患者160例,分为对照组与观察组。给予对照组咪达唑仑联用枸橼酸芬太尼;给予观察组右美托咪定。观察两组相关数据。结果观察组给药1h、3 h及5 h收缩压低于对照组,P <0.05;观察组镇痛镇静有效率为95.0%,与对照组的87.5%相比,差异无统计学意义,P> 0.05;观察组不良反应发生概率为60.00%,较之对照组的86.25%而言,显著更低。结论右美托咪定作用于成功撤机(> 12 h)COPD患者,镇痛镇静效果显著。

Objective To investigate the analgesic and sedative effects of dexmedetomidine on patients with chronic obstructive pulmonary disease (COPD) after weaning.Methods A total of 160 patients with COPD who have successfully withdrew (>12 h) from January 2017 to September 2018 were enrolled in the control group and the observation group.The control group was given midazolam in combination with fentanyl citrate;The observation group was given dexmedetomidine.The relevant data of the two groups w a s o b s e r v e d.Results The sys tolic b lood pressure of the observation group was lower than that of the control group at 1 h,3 h and 5 h,P < 0.05.The effective rate of analgesia sedation in the observation group was 95.0%,compared with the control group of 87.5%,the difference was not statistically significant,P > 0.05.The probability of adverse reactions in the observation group was 60.00%,which was significantly lower than that of the control group of 86.25%.Conclusion Dexmedetomidine is effective in patients with COPD who have successfully withdrew (>12 h).The analgesic effect is significant.