外泌体在胰腺癌诊断中的作用

Research advances in exosomes in diagnosis of pancreatic cancer

胰腺癌是死亡率极高的消化系统恶性肿瘤,外泌体是一种直径为30～200 nm,由多种细胞分泌释放到细胞外基质中的膜性囊泡结构,可以携带RNA、DNA、蛋白质和脂质等多种分子,并通过与靶细胞的结合介导细胞间的信息交流和调控细胞的生理功能。近年研究发现,外泌体不仅在胰腺癌的发生和发展中发挥重要作用,还有助于胰腺癌的早期诊断,并有望成为新的胰腺癌诊断标志物。阐述了外泌体在胰腺癌早期诊断中的研究进展。

Pancreatic cancer is a digestive system malignancy with high mortality. Exosomes are membranous vesicles with a diameter of 30-200 nm,which are released by various cells into the extracellular matrix. Exosomes can carry various molecules such as RNA,DNA,proteins,and lipids and bind to target cells to mediate the communication between cells and regulate the physiological function of cells. Recent studies have shown that exosomes play an important role in the development and progression of pancreatic cancer and can help with the early diagnosis of pancreatic cancer,and exosomes are expected to become a new biomarker for the diagnosis of pancreatic cancer. This article reviews the research advances in the role of exosomes in the early diagnosis of pancreatic cancer.