摘要
人载脂蛋白A-Ⅳ(apolipoprotein A-IV, ApoA-IV)主要由小肠和下丘脑合成分泌的一种含376氨基酸的46 ku糖蛋白,参与高密度脂蛋白的组成或以游离状态存在于血浆; ApoA-Ⅳ的遗传多态性中以Q360H和T347S两个亚型最常见; ApoA-Ⅳ不仅可介导反向胆固醇转运,而且有抗氧化和抗炎特性,因此循环ApoA-Ⅳ是一种脂质抗氧化剂和抗炎蛋白,在抗动脉粥样硬化中起重要作用。
Human apolipoprotein A-Ⅳ(ApoA-Ⅳ) is a 46 ku glycoprotein containing 376 amino acids mainly synthesized by the small intestine and hypothalamus, which participates in the composition of HDL or exists in plasma in a free state. Among the genetic polymorphisms of ApoA-IV, two subtypes of Q360H and T347S are the most common;ApoA-Ⅳ not only mediates reverse cholesterol transport, but also has antioxidant and anti-inflammatory properties, so circulating ApoA-Ⅳ is a lipid antioxidant and anti-inflammatory protein that acts in anti-AS important role.
作者
王铎
柳太云
WANG Duo;LIU Taiyun(Zunyi Medical Univeisity,Zunyi 563000,China;Guizhou Provincial People s Hospital,Zunyi 563000,China)
出处
《医学研究与教育》
CAS
2019年第2期8-12,共5页
Medical Research and Education
基金
贵州省省长资金临床应用课题专项研究[黔省专合字(2012)99号]
贵州省科技厅联合基金[黔科合LS字(2012)004号]
关键词
载脂蛋白A-Ⅳ
动脉粥样硬化
抗炎
抗氧化
apolipoprotein A-Ⅳ(ApoA-Ⅳ)
atherosclerosis
anti-inflammatory
anti-oxidation
