特异性AT序列结合蛋白2在颌面部发育及牙周组织再生中作用的研究进展

Research progress on the role of special AT-rich sequence binding protein 2 in maxillofacial development and periodontal regeneration

特异性AT序列结合蛋白(SATB)2是一种组织特异性表达的核基质序列结合蛋白。SATB2被鉴定为骨骼塑型和成骨细胞分化的分子决定因素,在颌面部发育中发挥关键作用,是有效的促进牙周再生的调控因子。本文就SATB2对颌面部发育的调控及其在牙周组织工程领域应用的研究现状进行综述。

Special AT-rich sequence binding protein 2 (SATB2) is a tissue-specific nuclear matrix sequence binding protein. SATB2 has been identified as a molecular determinant of osteogenesis and osteoblast differentiation, plays a key role in maxillofacial development and is an effective regulator of periodontal regeneration. This article reviews the current status of regulation of maxillofacial development by SATB2 and its application in periodontal tissue engineering.