基于多肽-金纳米粒子复合物的生物传感研究及应用进展

Research Progress on Biosensing Based on Peptides and Gold Nanoparticles Composite Materials

多肽是α-氨基酸以肽键连接在一起而形成的化合物,同时也是蛋白质水解的中间产物。金纳米粒子具有良好的生物相容性和突出的表面等离子共振性质,基于多肽-金纳米粒子体系的独特光学特性的生物传感研究及应用已引起众多科学工作者的关注。本文仅就近年来利用多肽-金纳米粒子复合物进行生物传感研究及应用加以评述,包括多肽和金纳米粒子的制备与特性、多肽-金纳米粒子复合物的组装以及其在生物传感中的应用等。

As the intermediate product of protein hydrolysis,peptides are synthesized through the polymerization ofα-amino acids.Given the great biocompatibility and surface plasmon resonance(SPR)of gold nanoparticles(AuNPs),biosensors based on the peptide-AuNPs system have attracted the attention of many scientists.In this review,the biosensing research and application of the peptide-AuNPs complexes are summarized,including the preparation and properties of peptides and AuNPs,the synthesis of peptide-AuNPs and the application in biosensing.