光热疗用GO-MoS_2纳米载体的构建及应用

Construction and application of graphene oxide-MoS_2 as a nanocarrier for photothermal therapy

采用水热法在氧化石墨烯(GO)表面生长MoS_2纳米片并枝接聚乙二醇(PEG)以改善其生物相容性。通过傅立叶变换红外光谱、透射电子显微镜等手段对GO-MoS_2复合材料进行表征,利用酶标仪、荧光共聚焦显微镜等对复合物及载药复合物的细胞毒性及细胞摄入进行了探究。结果表明,所制备的纳米复合材料相比于GO表现出更高的药物负载率和释放率,以及显著的光热转换性能,具有应用于光热疗法的潜力。

MoS2 nanosheets were grown on a graphene oxide (GO) surface by a hydrothermal method and the resul- ting composite was grafted with polyethylene glycol (PEG) to improve its biocompatibility. The GO-MoS2 compos- ite was characterized by FT-IR, TEM, and XPS. The cytotoxicity and cellular uptake of the composite and drug- loaded complex were investigated by using microplate readers and fluorescence confocal microscopy. The results show that the prepared composite nanomaterials have higher drug loading and release efficiencies than GO, as well as a promising photothermal conversion performance. The material therefore has the potential to be part of photo-thermal therapy.