未服用二甲双胍2型糖尿病患者发生轻度认知功能障碍的影响因素分析

Influencing factors of developing mild cognitive impairment in type 2 diabetes mellitus patients without oral administration of metformin

目的探讨未服用二甲双胍的2型糖尿病(T2DM)患者发生轻度认知功能障碍(MCI)的影响因素。方法选取149例未服用二甲双胍的T2DM患者,收集患者的一般资料、体格检查及实验室检查结果,分析未服用二甲双胍的T2DM患者发生MCI的影响因素。结果 149例T2DM患者中,98例发生MCI,发生率为65.8%。文化程度低、胱抑素C和糖化血红蛋白(HbA1c)升高是未服用二甲双胍的T2DM患者发生MCI的独立危险因素(P<0.05)。结论文化程度低、胱抑素C和HbA1c增高是未服用二甲双胍T2DM患者发生MCI的独立危险因素。

Objective To investigate the influencing factors of developing mild cognitive impairment(MCI) in patients with type 2 diabetes mellitus(T2DM) without oral administration of metformin. Methods A total of 149 T2DM patients without oral administration of metformin were enrolled,and their general data and physical examination and laboratory results were collected.The influencing factors of developing MCI in T2DM patients without oral administration of metformin were analyzed . Results Ninety-eight of the 149 patients with T2DM suffered from MCI,accounting for 65.8 %.Low educational level and increased cystatin C and hemoglobin A1c(HbA1c) were independent risk factors for developing MCI in T2DM patients without oral administration of metformin(all P <0.05). Conclusion Low educational level and increased cystatin C and HbA1c are independent risk factors for developing MCI in T2DM patients without oral administration of metformin.