细胞色素P450与基质金属蛋白酶-26在宫颈癌中的表达

Expression of Cytochrome P450 and Matrix Metalloproteinase-26 in Cervical Cancer

目的探讨CYP1A1及MMP-26在正常子宫颈、宫颈上皮内瘤变(CIN)、宫颈癌中的表达及临床意义。方法采用免疫组织化学法检测CYP1A1及MMP-26在35例正常子宫颈、46例CIN、29例宫颈癌中的表达情况。结果 CIN组、宫颈癌组织中CYP1A1及MMP-26的表达明显高于正常宫颈组织,差异有统计学意义。二者宫颈癌癌中的表达明显高于宫颈上皮内瘤变组织,差异有统计学意义。在CIN不同病理分级中,CINⅢ中的阳性表达明显高于CINⅡ级、CINⅠ级,而CINⅡ级与CINⅠ级比较无统计学意义(P>0.05)。结论 CYP1A1及MMP-26的表达与宫颈癌的形成与发展有着密切的关系。

Objective To study the expression of cytochrome P4501 A1(CYP1 A1)and matrix metalloproteinase-26(MMP-26)in normal cervical tissue,cervical intraepithelial neoplasia(CIN),and cervical cancer.Methods The expression of CYP1 A1 and MMP-26 in 35 cases of normal cervix,46 cases of CIN,29 cases of cervical cancer were studied by immunohistochemistry.Rusults The positive expression rates of CYP1 A1 and MMP-26 in CIN,cervical cancer were higher than those in normal cervical tissue,which had statistic significance.The positive expression rates of both in cervical cancer were higher than those in CIN.The positive expression rates of CYP1 A1 and MMP-26 in CINⅢwere higher than those in CINⅡand CINⅠ.The expression difference of both in CINⅡand CINⅠhad no statistic significance(p>0.05).Conclusions The expression of CYP1 A1 and MMP-26 protein is closely related to the formation and development of cervical cancer.