参麦注射液对肿瘤放射性口腔黏膜炎临床疗效

Clinical effect of Shenmai injection on radiation-induced oral mucositis in head and neck neoplasms

目的探讨参麦注射液对肿瘤放射性口腔黏膜炎治疗作用的研究。方法 120例均明确临床诊断为头颈部肿瘤,全部接受放射治疗。将患者随机分为2组:对照组60例,予以常规对症治疗;观察组60例,在对症治疗的基础上加入参麦注射液治疗。两组的给予调强放射治疗,1.82～2.18 Gy/次,1次/d,5次/周,放疗总剂量60～71.96 Gy。结果观察组较对照组放射性口腔黏膜炎出现时间较迟、复原时间较快(P<0.05);两组中重度放射性口腔黏膜炎发生率分别为观察组20%、对照组80%(P<0.01);观察组患者平均放疗时间明显低于对照组(P<0.05)。结论参麦注射液能明显减轻患者出现放射性口腔黏膜炎的症状,保证放疗按时完成,提高了生活质量,具有较好的临床推广价值。

Objective To investigate the therapeutic effect of Shenmai injection on radiation induced oral mucositis in head and neck neoplasms. Methods 120 cases were diagnosed as head and neck neoplasms, all of which received radiation therapy. The patients were randomly divided into two groups, 60 cases in each group. The control group received routine symptomatic treatment;the observation group was given Shenmai injection more. Both groups were given intensity-modulated radiation therapy: 1.82 to 2.18 Gy once daily, 5 days per week, and the total dose of radiotherapy was 60- 71.96 Gy. Results Compared with control group, the radioactive oral mucositis appeared later and the recovery time was shorter in observation group, with significant difference ( P < 0.05 ).The incidence of moderate and severe radioactive oral mucositis in the two groups was 20% in observation group and 80% in control group, respectively ( P < 0.01 ). The average radiotherapy time in observation group was significantly shorter than that in control group, with significant difference( P < 0.05 ). Conclusion Shenmai injection can significantly alleviate the symptoms of radioactive oral mucositis in patients, ensure that radiotherapy is completed on time, improve the quality of life, and has good clinical promotion value.