摘要
单克隆免疫球蛋白病由一组异质性疾病组成,以血或尿中存在单克隆免疫球蛋白为特征表现,此类疾病临床表现多样,神经功能异常为其中之一。本院收治1例单克隆免疫球蛋白血症合并神经功能异常患者,确诊为Bing-Neel综合征,给予美罗华600 mg d1+氟迷拉滨40 mg d2～4+环磷酰胺0.3 g d2～4(RFC方案)化疗,同时联合鞘内注射,临床症状明显改善。
Monoclonal immunoglobulin disease is comprised of a group of heterogeneous diseases,which is characterized by the presence of monoclonal immunoglobulin in blood or urine. The clinical manifestations of the disease are versatile,and neurological dysfunction is one of the clinical manifestations. In our hospital, a patient with monoclonal immunoglobulinemia complicated with neurological dysfunction was diagnosed as Bing-Neel syndrome, given RFC regimen chemotherapy(rituximab 600 mg d1+flumurabin 40 mg d2-4+cyclophosphamide 0.3 g d2-4), combined with intrathecal injection, the patient's clinical symptoms improved significantly.
作者
罗添丞
卢静
强婉婷
傅卫军
杜鹃
Luo Tiancheng;Lu Jing;Qiang Wanting;Fu Weijun;Du Juan(Department of Hematology, Changzheng Hospital of the Second Military Medical University,National Center for Myeloma and Lymphoma, Shanghai 200003, China)
出处
《临床荟萃》
CAS
2019年第4期352-355,共4页
Clinical Focus
关键词
单克隆免疫球蛋白病
神经功能异常
诊断
治疗
monoclonal gammopathies
abnormal neurological function
diagnosis
treatment
