早期肠内营养联合益生菌治疗脓毒症休克患者的疗效观察

Therapeutic effect of early enteral nutrition combined with probiotics on patients with septic shock

目的探讨早期肠内营养支持联合益生菌治疗脓毒症休克患者的临床效果。方法选取2015年4月至2017年11月本院收治的脓毒症合并休克患者66例为研究对象,按入院顺序随机分为观察组(32例)与对照组(34例)。对照组患者给予早期肠内营养支持治疗,观察组患者在对照组治疗的基础上加用益生菌治疗,比较两组患者的临床治疗效果。结果连续治疗2周后,两组患者的血清总蛋白、血红蛋白、血清白蛋白均显著提高,观察组患者这三个指标的水平均显著高于对照组(P <0. 05);观察组患者的机械通气及ICU住院时间均显著短于对照组(P <0. 05);两组患者的住院病死率比较差异无统计学意义(P> 0. 05)。结论早期肠内营养支持联合益生菌治疗能显著改善脓毒症休克患者的营养状况,缩短患者机械通气时间和住院治疗时间,对指导临床治疗具有重要的意义。

Objective To explore the clinical effect of early enteral nutrition support combined with probiotics in the treatment of patients with septic shock. Methods 66 patients with sepsis and shock admitted to our hospital from April 2015 to November 2017 were selected as subjects and randomly divided into observation group (32 cases) and control group ( 34 cases ) according to the order of admission. The patients in the control group were given early enteral nutrition support treatment, and the patients in the observation group were treated with probiotics on the basis of the treatment of the control group. The clinical effects of the two groups of patients were compared. Results After 2 weeks of continuous treatment, serum total protein, hemoglobin, and serum albumin were significantly increased in both groups, the levels of these three indicators in the observation group were significantly higher than those in the control group ( P <0.05). The mechanical ventilation and ICU hospitalization time in the observation group were significantly shorter than those in the control group ( P <0.05 ). There was no significant difference in hospital mortality between the two groups ( P >0.05). Conclusion Early enteral nutrition support combined with probiotics treatment can significantly improve the nutritional status of patients with septic shock, shorten the mechanical ventilation time and hospitalization time. It is of great significance to guide clinical treatment.