LEEP术后干扰素凝胶联合保妇康栓对CIN Ⅲ患者疗效及炎症因子水平的影响

The curative effect of interferon gel combined with Baofukang suppository for treating women with CIN Ⅲ after Loop electrosurgical excisional procedure and its influence on the level of inflammatory factors

目的:观察LEEP术后干扰素凝胶联合保妇康栓治疗高级别宫颈上皮内瘤变(CINⅢ)疗效及对炎症因子水平的影响。方法:2015年9月—2017年5月本院接受治疗的CINⅢ患者176例,按照随机数字表方法分为对照组和观察组各88例,LEEP术后对照组予以保妇康栓治疗,观察组予以保妇康栓联合重组人干扰素α2b凝胶治疗,检测两组术后1个月血清TNF-α和hs-CRP水平,统计创面愈合时间,比较两组治疗后CIN疗效及高危型人乳头瘤病毒(HPV)转阴情况,观察术后并发症和治疗结束后1年内CIN复发情况。结果:观察组术后宫颈创面愈合时间(17.5±3.6)d短于对照组(25.2±4.2)d(P=0.000);两组术后1个月血清TNF-α和hs-CRP水平均较治疗前下降,且观察组低于对照组(P<0.05);两组CIN治疗有效率(94.3%、95.45%)无差异(P=0.732),观察组治疗后高危型HPV转阴率(92.9%)高于对照组(66.2%)(P=0.000),术后并发症(8.0%)及1年内CIN复发率(2.4%)均低于对照组(19.3%、11.9%)(P=0.028、0.018)。结论:LEEP术后干扰素凝胶联合保妇康栓治疗CINⅢ,可显著下调宫颈炎症反应程度,缩短创面愈合时间,促进高危型HPV转阴率,并降低术后并发症及CIN复发风险。

Objective: To observe the curative effect of interferon gel combined with Baofukang suppository for treating women with CIN Ⅲ after Loop electrosurgical excisional procedure (LEEP), and to analyze its influence on the level of inflammatory factors of women. Methods: 176 women with CIN Ⅲ who had experienced LEEP were as the research objects from May 2017 to September 2015. All the women were divided into control group (n=88) and study group (n=88) according to random number table. The women in control group were treated by Baofukang suppository, and the women in study group were treated by Baofukang suppository combined interferon gel. The serum levels of TNF-α and hs-CRP of all women were detected at 1 month after LEEP operation. The wound healing time of all women was counted. The curative effect, the rate of high risk HPV turned to negative, postoperative complication rate, and the recurrence rate of CIN within 1 years after treatment were compared between the two groups. Results: The healing time of the cervical wound of women (17.5±3.6d) in study group was significant shorter than that (25.2±4.2 d) of women in control group ( P =0.000). 1 month after LEEP, the serum levels of TNF-α and hs-CRP were significantly decreased, and the serum levels of TNF-α and hs-CRP of women in study group were significant lower than those of women in control group ( P <0.05). There was no significant different in the effective rate (94.3% VS. 95.5%) between the two groups ( P =0.732>0.05). The rate of high risk HPV turned to negative of women in study group (92.9%) was significant higher than that(66.2%) of women in control group ( P =0.000). The incidence of postoperative complications (8.0%) and CIN recurrence rate during 1 year (2.41%) of women in study group were significant lower than those (19.3% and 11.9%) of women in control group ( P =0.028, 0.018). Conclusion: Interferon gel combined with Baofukang suppository for treating women with CIN Ⅲ after LEEP can significantly decrease the inflammation reaction degree, shorten wound healing time, promote the high-risk HPV turned to negative, and reduce the risk of complications and recurrence of CIN, so it is worthy of gynecology clinical application.