两种不同方案在卵巢低反应患者中的应用

Application of two different treatment protocols for patients with poor ovarian response

目的:比较不同促排方案在卵巢低反应患者中的应用效果。方法:回顾性分析2014年6月—2015年6月本院生殖中心卵巢低反应者应用克罗米芬+促性腺激素(CC+Gn)方案(245例)或常规长方案(110例)促排卵行IVF助孕的临床资料。结果:CC+Gn方案组Gn使用天数(9.5±2.1)d和Gn使用剂量(1325.5±566.1)U均低于长方案组(11.4±1.6)d、(2103.8±865.3)U,差异有统计学意义(P<0.05);冻融周期囊胚形成率(48.1%)、囊胚解冻移植妊娠率(30.3%)高于长方案组(P<0.05)。结论:CC+Gn促排方案是卵巢低反应患者可采用的方案之一。

Objective: To explore the value of two different treatment protocols in vitro fertilization and embryo transfer (IVF-ET) of patients with poor ovarian response. Methods: A retrospective study about 355 cycles of patients with poor ovarian response who had received IVF-ET was conducted. The patients were divided into group A (GnRH-a long protocol) and group B (CC+Gn protocol). Results: The Gn days of patients in group A was significant lower than that of patients in group B ( P <0.05). There were no significant different in the total fertility rate, high-quality embryo rate, and fresh cycle pregnancy rate between the two groups (P >0.05). The rates of total fertility, embryo quality, and fresh cycle pregnancy of patients in group A were significant lower than those of patients in group B ( P <0.05), but rates of blastocyst formation and frozen-thaw cycle pregnancy of patients in group A were significant higher than those of patients in group B ( P <0.05). Conclusion:The CC+Gn protocol is one of the effect protocols for treating patients with poor ovarian response.