冠心病患者合并甲状腺功能减退的危险因素分析

Risk factors for complication of hypothyroidism in patients with coronary heart disease

目的分析冠心病患者合并甲状腺功能减退的危险因素。方法选取357例冠心病患者,将156例合并甲状腺功能减退的患者纳入观察组,201例单纯冠心病患者纳入对照组。比较两组的血脂、血糖、超敏C反应蛋白(hs-CRP)水平。采用Logistic回归模型分析冠心病患者合并甲状腺功能减退的危险因素。结果与对照组相比,观察组HDL-C水平降低,LDL-C及血糖水平升高(均P <0. 05)。血糖升高、HDL-C降低均是冠心病患者合并甲状腺功能减退发生的独立危险因素(均P <0. 05)。结论正常范围内低HDL-C水平、高血糖水平的冠心病患者发生甲状腺功能减退的风险较大,需监测其甲状腺功能的变化。

Objective To analyze the risk factors for complication of hypothyroidism in patients with coronary heart disease(CHD). Methods A total of 357 CHD patients were recruited,among which 156 patients complicated with hypothyroidism were enrolled as observation group and 201 patients with CHD alone as control group.Levels of blood lipid,blood glucose and high-sensitivity C-reactive protein(hs-CRP) were compared between the two groups. Logistic regression model was used to analyze risk factors for complication of hypothyroidism in CHD patients. Results Compared with the control group,the observation group exhibited decreased HDL-C level and increased levels of LDL-C and blood glucose(all P <0.05).Both increased blood glucose and decreased HDL-C were independent risk factors for complication of hypothyroidism in CHD patients(all P <0.05). Conclusion CHD patients with low-level HDL-C and high-level blood glucose within normal limits are at higher risk of hypothyroidism,and need monitoring changes in their thyroid function.