静息心率与颈动脉斑块及其稳定性的关系

Relationship of resting heart rate with occurrence and stability of carotid artery plaque

目的探讨静息心率与颈动脉斑块及其稳定性的关系。方法纳入219例脑血管疾病患者为研究对象,测定其静息心率,并行血生化指标及颈动脉超声检查。根据入院时静息心率测量值将患者分为A组54例(静息心率<67次/min)、B组55例(67次/min≤静息心率<76次/min)、C组52例(76次/min≤静息心率<82次/min)及D组58例(静息心率≥82次/min)。比较4组颈动脉斑块及不稳定斑块检出率,采用多因素Logistic回归模型分析静息心率与颈动脉斑块稳定性的相关性。结果 A组的颈动脉斑块检出率及不稳定斑块检出率高于B组,而B组、C组、D组颈动脉斑块检出率及不稳定斑块检出率均依次升高(均P <0. 05)。静息心率≥82次/min是颈动脉斑块稳定性的危险因素(P <0. 05)。在男性人群中,静息心率≥82次/min是颈动脉斑块稳定性的危险因素(P <0. 05),但在女性人群中,静息心率与颈动脉斑块稳定性无相关性(P> 0. 05)。结论静息心率水平的升高可能与颈动脉斑块的形成有关;静息心率增快者尤其是男性,颈动脉斑块不稳定的风险增高。

Objective To explore the relationship of resting heart rate with occurrence and stability of carotid artery plaque. Methods A total of 219 patients with cardiovascular disease were enrolled as subjects,then their resting heart rates were determined,and blood biochemical indicators testing and carotid artery ultrasound were performed.The patients were divided into group A(resting heart rate<67 beats/min, n =54),group B(67 beats/min≤resting heart rate<76 beats/min, n =55),group C(76 beats/min≤resting heart rate<82 beats/min, n =52) and group D(resting heart rate≥82 beats/min, n =58) according to the resting heart rate measured at admission.The detection rates of carotid artery plaque and unstable carotid artery plaque were compared among the four groups,multivariate Logistic regression model was used to analyze the correlation of resting heart rate with stability of carotid artery plaque. Results The detection rates of carotid artery plaque and unstable carotid artery plaque in group A were higher than those in group B,and detection rates of carotid artery plaque and unstable carotid artery plaque increased in group B,group C and group D successively(all P <0.05).Resting heart rate≥82 beats/min was risk factor for stability of carotid artery plaque in the male( P <0.05),but resting heart rate did not correlate with stability of carotid artery plaque in the female ( P >0.05). Conclusion Increased resting heart rate is probably related to the occurrence of carotid artery plaque;the risk for instability of carotid artery plaque is higher in the individuals with faster resting heart rate, especially in the male.