降钙素原在卒中相关性肺炎中的研究进展

Research Progress of Procalcitonin in Stroke-Associated Pneumonia

降钙素原(PCT)是一种在严重感染,特别是细菌感染条件下释放到患者循环系统中的可溶性蛋白,其水平与感染严重程度有关。PCT在卒中相关性肺炎(SAP)中的研究较少,其对SAP的特异性、敏感性及相关影响因素仍存在争议。SAP是导致卒中患者致残率和死亡率增高的重要原因,而卒中患者早期神经功能损伤的发病率较高,通过观察PCT动态变化及PCT清除率可评估SAP患者的预后。PCT联合其他感染指标如C反应蛋白、白细胞计数等可提高诊断SAP的灵敏度和特异度。

Procalcitonin (PCT) is a soluble protein released into the patient′s circulatory system under severe systemic infections,especially bacterial infections.Its level is related to the severity of infection.PCT is less studied in stroke-associated pneumonia(SAP),and its specificity,sensitivity and related influencing factors are still controversial.SAP is an important reason for the increase of disability and mortality in stroke patients,and the incidence of early neurological impairment is higher in stroke patients,and the prognosis of patients is assessed by observing the dynamic changes and clearance rate of PCT.PCT combined with other infection indicators such as C-reactive protein,white blood cell count can improve the sensitivity and specificity of diagnosis of SAP.