维生素D调节肠道炎症反应的研究进展

Research Advances in Mechanism of Vitamin D Regulating Intestinal Inflammation

维生素D通过与维生素D受体结合发挥多种生物学功能。维生素D在肠道炎症中有重要作用。它通过调节肠道屏障的紧密连接和抑制上皮细胞凋亡来保持肠道黏膜屏障的结构完整和正常功能,通过核苷酸结合寡聚化结构域2/核因子κB途径、激活Toll样受体上调抗菌肽的表达和保持自噬功能。另外,它抑制Th1细胞介导的免疫应答,促进Th2细胞产生抑制肠道炎症的细胞因子,并且调节肠道菌群,通过保护肠道生态平衡抑制肠道炎症。因此,对维生素D及其受体调节肠道炎症机制的进一步研究,将为临床上治疗肠道炎症提供新思路。

Vitamin D exerts a variety of biological functions by binding to the vitamin D receptor.Vitamin D plays an important role in intestinal inflammation.It maintains the structural integrity and normal function of the intestinal mucosal barrier by regulating the tight junction of the intestinal barrier and inhibiting the apoptosis of epithelial cells.It up-regulates the expression of antimicrobial peptides and maintains autophagy through the nucleotide oligomerization domain2/nuclear factor -κB pathway and activation of Toll-like receptors.In addition, it inhibits Th1 cell- mediated immune responses, promotes Th2 cells to produce cytokines that inhibit intestinal inflammation,regulates intestinal flora,and inhibits intestinal inflammation by keeping the intestinal ecological balance.Therefore,further research on the regulation mechanism of intestinal inflammation by vitamin D and its receptors will provide new ideas for the clinical treatment of intestinal inflammation.